Structural characterization of persistent tympanic membrane perforations in man

The Laryngoscope
O SpandowM Dahlström

Abstract

In the present structural study the authors investigated the border of permanent tympanic membrane (TM) perforations in patients selected for myringoplasty. Furthermore, a panel of monoclonal antibody markers that recognize different epitopes within glycosaminoglycans as well as antibodies to epidermal growth factor and fibronectin were applied to the sections. In half of the specimens the epithelial junction ended at the inside of the perforation border, whereas in the other half it was located at the perforation border itself. In the junctional area the keratinocytes were covered by a thick keratin layer which protruded as a spur centripetally in order to bridge the perforation. Epidermal cells formed papillae and contained remnants of keratinocyte nuclei that showed similarities to those of the skin in inflammatory conditions. The connective tissue layer was fibrous and showed areas containing sclerotic plaques. The inner epithelium of the TM had abundant ciliae, thus supporting the concept that cells of the mucosal lining of the TM are able to differentiate in inflammatory conditions into ciliated cells and secretory cells. The immunoreactivity of hyaluronan and other glycosaminoglycans, the immunoreactivity of epidermal gr...Continue Reading

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Citations

Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·C Laurent, S Hellström
May 2, 2007·The Journal of Laryngology and Otology·K GörürC Ozcan
Oct 4, 2012·Tissue Engineering. Part B, Reviews·Bing Mei TehMarcus D Atlas
Oct 25, 2012·Tissue Engineering. Part a·Yi ShenRobert Jeffery Marano
Nov 9, 2011·Expert Opinion on Biological Therapy·Bing Mei TehRobert J Marano
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Jul 26, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Peter L Santa MariaReza Ghassemifar
Sep 9, 2010·The Laryngoscope·Peter Luke Santa MariaReza Ghassemifar
Dec 3, 2014·International Journal of Pediatric Otorhinolaryngology·Allen Y WangRodney J Dilley
Sep 8, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Adela Cordero DevesaIgnacio Cobeta Marco

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