Structural characterization of pollen allergens.

Clinical Reviews in Allergy & Immunology
Petra Verdino

Abstract

The molecular characterization of allergens has accelerated significantly since the widespread implementation of modern analytical methods. The combination of gene cloning and heterologous protein expression has generated an extensive array of allergens that is available for comparative analysis, as well as clinical applications. Several internet-accessible allergen databases integrate the accumulated information from biomedical research and clinical practice. Innovations in classical biophysical methods, such as mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy, have rendered complex biological macromolecules amenable to detailed structural analysis. The modern scientific era has realized the synthesis of bioinformatics, molecular biology, biochemistry, biophysics, and immunology, and given us the means needed to decipher the remaining mysteries of allergies. This article addresses how the synergism of modern scientific techniques has hastened our understanding of allergies, how these techniques are applied in the identification and characterization of allergens, and how these methods assist the rational development of clinical tools for allergy diagnosis and treatment.

Citations

Oct 12, 2012·Molecular Biology Reports·Yubao Cui
Aug 7, 2008·Current Allergy and Asthma Reports·Anna Pomés
Jan 4, 2008·Clinical Reviews in Allergy & Immunology·Yaniv ShererYehuda Shoenfeld
Jan 15, 2008·Clinical Reviews in Allergy & Immunology·Pierre Youinou
May 31, 2007·International Archives of Allergy and Immunology·Philip E TaylorM Michael Glovsky
Nov 8, 2017·Journal of Natural Products·Alen BožičevićMatthias Hamburger

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