Nov 13, 2019

Structural characterization of polysaccharides from three seaweed species and their hypoglycemic and hypolipidemic activities in type 2 diabetic rats

International Journal of Biological Macromolecules
Rui-Bo JiaMouming Zhao


Three algal polysaccharides (APs) were acquired from Scagassum (SCP), Sargassum fusiforme(Harv.) Setch. (SFP) and Macrocystis pyrifera(L.)Ag. (MAP) by hot water extraction, and their structural characterization and antidiabetic activity were investigated in high fat diet and streptozotocin-induced type 2 diabetic rats. The results revealed that there were obvious differences in extraction yield, molecular weight, compositions of monosaccharide and organic element, molecular morphology, rheological properties and the contents of total sugar, protein, uronic acid and sulfate of SCP, MAP and SFP. SFP had the highest extraction yield, the contents of total sugar and uronic acid and the smallest molecular weight. Congo red assay indicated that all polysaccharides had no triple-helix structure. Oral administration of APs prominently restrained loss of weight and increase of water intake (P < .05), and also significantly controlled the increase of levels of blood glucose, triglyceride (TG) and total cholesterol (TC) in diabetic rats (P <0 .05). Diabetic rats treated with SCP had the highest high density lipoprotein cholesterol (HDL-C) level (P < .05), similar to those in normal group. MAP and SCP showed positive effect in improving th...Continue Reading

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Mentioned in this Paper

Diabetes Mellitus, Non-Insulin-Dependent
Triple Helix (Molecular Structure)
Algal Proteins
Kelp, Giant
Cerebral Palsy, Spastic
Sargassum fusiforme

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