PMID: 9171426Jun 1, 1997Paper

Structural characterization of the lipids A of three Bordetella bronchiseptica strains: variability of fatty acid substitution

Journal of Bacteriology
H ZarroukM Caroff

Abstract

The structures of lipids A isolated from the lipopolysaccharides (LPSs; endotoxins) of three different pathogenic Bordetella bronchiseptica strains were investigated by chemical composition and methylation analysis, gas chromatography-mass spectrometry, nuclear magnetic resonance, and plasma desorption mass spectrometry (PDMS). The analyses revealed that the LPSs contain the classical lipid A bisphosphorylated beta-(1-->6)-linked D-glucosamine disaccharide with hydroxytetradecanoic acid in amide linkages. Their structures differ from that of the lipid A of Bordetella pertussis endotoxin by the replacement of hydroxydecanoic acid on the C-3 position with hydroxydodecanoic acid or dodecanoic acid and the presence of variable amounts of hexadecanoic acid. The dodecanoic acid is the first nonhydroxylated fatty acid to be found directly linked to a lipid A glucosamine. The lipids A were heterogeneous and composed of one to three major and several minor molecular species. The fatty acids in ester linkage were localized by PDMS of chemically modified lipids A. B. pertussis lipids A are usually hypoacylated with respect to those of enterobacterial lipids A. However, one of the three B. bronchiseptica strains had a major hexaacylated mo...Continue Reading

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Citations

Oct 25, 2007·Journal of Endotoxin Research·Iain MacArthurAndrew Preston
Jun 3, 2005·Journal of Lipid Research·Asmaa El HamidiMartine Caroff
Nov 20, 2008·Journal of Lipid Research·Asmaa El HamidiMartine Caroff
May 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Judy GopalHui-Fen Wu
Apr 25, 2000·Rapid Communications in Mass Spectrometry : RCM·L AusselM Caroff
Mar 13, 2002·The Journal of Biological Chemistry·Charles R SweetChristian R H Raetz
Aug 1, 2012·Rapid Communications in Mass Spectrometry : RCM·Adriana C CasabuonoAlicia S Couto
Jul 11, 2002·Microbes and Infection·Martine CaroffNicole Haeffner-Cavaillon
Dec 13, 2003·Carbohydrate Research·Martine Caroff, Doris Karibian
Jun 14, 2019·Journal of the American Society for Mass Spectrometry·Adriana C CasabuonoAlicia S Couto
Feb 2, 2016·Environmental Science & Technology·Richard E CochranElizabeth A Stone

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