PMID: 2492662Feb 1, 1989Paper

Structural characterization of toxic cyclic peptides from blue-green algae by tandem mass spectrometry

Proceedings of the National Academy of Sciences of the United States of America
T KrishnamurthyS Missler

Abstract

Combined use of chemical degradation, derivatization, and tandem mass spectrometry for rapid structural characterization of toxic cyclic peptides from blue-green algae at the nanomole level is described. Previously, all blue-green algal toxins were thought to belong to a family of seven-residue cyclic peptides, having the general structure cyclo-D-Ala-L-Xaa-erythro-beta-methyl-D-isoaspartic acid-L-Yaa-Adda-D-isoglutamic acid-N-methyldehydroalanine, where Xaa and Yaa represent variable amino acids of the L configuration and Adda is 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Structural characterization of two additional toxins indicates that further variability can exist within this family of naturally occurring toxic cyclic peptides. Isoaspartic acid and dehydroalanine can substitute for beta-methylisoaspartic acid and N-methyldehydroalanine, respectively.

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Citations

Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·J A MeriluotoJ E Eriksson
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·R D StonerH W Siegelman
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