Structural connectivity subserving verbal fluency revealed by lesion-behavior mapping in stroke patients

Neuropsychologia
Mingyang LiZaizhu Han

Abstract

Tests of verbal fluency have been widely used to assess the cognitive functioning of persons, and are typically classified into two categories (semantic and phonological fluency). While widely-distributed divergent and convergent brain regions have been found to be involved in semantic and phonological fluency, the anatomical connectivity underlying the fluency is not well understood. The present study aims to construct a comprehensive white-matter network associated with semantic and phonological fluency by investigating the relationship between the integrity of 22 major tracts in the whole brain and semantic fluency (measured by 3 cues) and phonological fluency (measured by 2 cues) in a group of 51 stroke patients. We found five left-lateralized tracts including the anterior thalamic radiation (ATR), inferior fronto-occipital fasciculus (IFOF), uncinate fasciculus (UF), superior longitudinal fasciculus (SLF) and frontal aslant tract (FAT) were significantly correlated with the scores of both semantic and phonological fluencies. These effects persisted even when we ruled out the influence of potential confounding factors (e.g., total lesion volume). Moreover, the damage to the first three tracts caused additional impairments i...Continue Reading

References

Sep 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·C D FrithP F Liddle
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·A Rosser, J R Hodges
Aug 22, 1996·Proceedings. Biological Sciences·C J MummeryR J Wise
May 1, 1997·Brain and Language·R M RuffH S Levin
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·J D GabrieliJ E Desmond
May 2, 1998·Journal of Cognitive Neuroscience·A Caramazza, J R Shelton
Apr 29, 1998·Neuropsychology·J V Baldo, A P Shimamura
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·R SchlösserJ D Brodie
Dec 31, 1998·Journal of Cognitive Neuroscience·C J PriceS J Frackowiak
Jul 19, 2001·Journal of the International Neuropsychological Society : JINS·J V BaldoE Kaplan
Aug 21, 2002·Journal of Clinical and Experimental Neuropsychology·Barbara RavnkildeAnders Gade
Apr 22, 2003·Nature Neuroscience·Elizabeth BatesNina F Dronkers
Oct 31, 2003·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Ysbrand D Van der WerfHarry B M Uylings
Mar 24, 2004·Cognition·P Indefrey, W J M Levelt
Apr 22, 2004·Neuropsychology·Julie D Henry, John R Crawford
Aug 27, 2004·Schizophrenia Research·Tania Jane PhillipsSimon L Collinson
Dec 14, 2004·Journal of Clinical and Experimental Neuropsychology·R L BillingsleyA C Papanicolaou
Dec 6, 2005·Biological Psychiatry·Todd LenczBarbara A Cornblatt
Sep 14, 2006·Annual Review of Psychology·Alex Martin
Oct 27, 2006·Journal of the International Neuropsychological Society : JINS·Juliana V BaldoNina F Dronkers
Nov 24, 2006·Brain : a Journal of Neurology·Michel DesmurgetHugues Duffau
Feb 1, 2007·Brain : a Journal of Neurology·Emmanuel MandonnetHugues Duffau
Feb 13, 2007·Brain : a Journal of Neurology·Jeremy D SchmahmannVan J Wedeen
Jun 23, 2007·Journal of Cognitive Neuroscience·Chris RordenLeonardo Bonilha
Nov 28, 2007·AJNR. American Journal of Neuroradiology·J I BreierA C Papanicolaou
Jun 27, 2008·Journal of Cognitive Neuroscience·Carin WhitneyTilo Kircher

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Citations

May 16, 2020·Journal of Neuropsychology·Melissa ThyeDaniel Mirman
Jun 20, 2020·Neurological Research·Zafer KeserFlavia M Nelson
Aug 20, 2020·Brain Structure & Function·Jérôme CochereauGuillaume Herbet
Mar 12, 2020·Brain Structure & Function·Antonino Vallesi, Laura Babcock
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Agnès BenvenuttoLejla Koric
Jan 26, 2021·Frontiers in Psychiatry·Penny KaramaounaStella G Giakoumaki
Dec 24, 2019·Neuropsychologia·Lisa CipolottiEdgar Chan
Mar 19, 2021·Frontiers in Neurology·Emanuele La CorteGraziano Serrao
Jun 9, 2021·CNS Neuroscience & Therapeutics·Wei ShanQun Wang
Jun 22, 2021·Frontiers in Neurology·Anna G M TempJohannes Prudlo
Aug 28, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·J Matthijs BiesbroekGeert Jan Biessels

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