Structural correlates of a regulatory idiotope.

Immunological Reviews
C Victor-KobrinC Bona

Abstract

The A48RI expressed on the ABPC48 and UPC10 beta 2----6 fructosan-binding myeloma proteins is a conformational antigenic determinant encoded by V genes deriving from the VHX24 and VK10 families. In the preimmune repertoire the clones using VHX24 genes rarely express A48 idiotopes, clearly demonstrating that this regulatory idiotope is a minor or silent idiotope. Furthermore, these same VHX24-utilizing preimmune clones are frequently associated with the VK1 gene family which is highly represented in the neonatal and adult repertoires. The clonal expansion occurring subsequent to neonatal injection of minute amounts of anti-Id antibodies leads to selective expansion of A48Id+ clones associated with class switching. Few somatic mutations are observed in preimmune clones, or in those expanded by anti-Id antibodies. The fact that few mutations were observed in the IgG1 clones obtained from animals injected with anti-A48Id antibodies after birth indicates that, in contrast to antigen-induced class-switching, the anti-Id-induced switching is not associated with a highly active mutational process. In contrast to the preimmune clones, or those expanded by anti-Id (in the absence of antigenic stimulation) in which VHX24 is associated wit...Continue Reading

References

Apr 1, 1986·Immunological Reviews·T Kieber-Emmons, H Kohler
May 1, 1989·The Journal of Experimental Medicine·A KaushikG Kelsoe
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I Sanz, J D Capra
Jan 1, 1981·Annales d'immunologie·D KovatchevS Avrameas
Jan 1, 1984·Annales d'immunologie·W T HumD M Gibson
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T Manser, M L Gefter
Jan 1, 1982·The Journal of Experimental Medicine·Y Kurosawa, S Tonegawa
Sep 1, 1983·The Journal of Experimental Medicine·P Legrain, G Buttin
Apr 1, 1981·The Journal of Experimental Medicine·J HiernauxP J Baker
Oct 1, 1975·European Journal of Immunology·K Eichmann, K Rajewsky

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Citations

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A KaushikG Kelsoe
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J J MarchalonisA B Edmundson
Jan 1, 1992·International Reviews of Immunology·J UrbainF Willems
Sep 1, 1991·European Journal of Immunology·C H SongM A Keller

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