Structural cortical network reorganization associated with early conversion to multiple sclerosis.

Scientific Reports
C TurA T Toosy

Abstract

Brain structural covariance networks (SCNs) based on pairwise statistical associations of cortical thickness data across brain areas reflect underlying physical and functional connections between them. SCNs capture the complexity of human brain cortex structure and are disrupted in neurodegenerative conditions. However, the longitudinal assessment of SCN dynamics has not yet been explored, despite its potential to unveil mechanisms underlying neurodegeneration. Here, we evaluated the changes of SCNs over 12 months in patients with a first inflammatory-demyelinating attack of the Central Nervous System and assessed their clinical relevance by comparing SCN dynamics of patients with and without conversion to multiple sclerosis (MS) over one year. All subjects underwent clinical and brain MRI assessments over one year. Brain cortical thicknesses for each subject and time point were used to obtain group-level between-area correlation matrices from which nodal connectivity metrics were obtained. Robust bootstrap-based statistical approaches (allowing sampling with replacement) assessed the significance of longitudinal changes. Patients who converted to MS exhibited significantly greater network connectivity at baseline than non-conv...Continue Reading

References

Jun 12, 1998·Nature·D J Watts, S H Strogatz
Nov 3, 2001·Physical Review Letters·V Latora, M Marchiori
Jun 24, 2008·Annals of Neurology·Leonora K FisnikuDavid H Miller
Aug 16, 2008·Lancet Neurology·Jeroen J G Geurts, Frederik Barkhof
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Feb 27, 2010·Annals of Neurology·Thomas M JenkinsAlan J Thompson
Jul 20, 2010·NeuroImage·Martin ReuterBruce Fischl
Feb 8, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·T M JenkinsA T Toosy
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
Mar 28, 2013·Nature Reviews. Neuroscience·Aaron Alexander-BlochEd Bullmore
Mar 29, 2013·PloS One·Betty M TijmsFrederik Barkhof
May 29, 2013·NeuroImage·Alan C Evans
Oct 15, 2013·Lancet Neurology·Massimo FilippiMaria A Rocca
Oct 22, 2013·Functional Neurology·Jonathan D Clayden
Feb 21, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Rebecca S SamsonDeclan T Chard
Jul 24, 2014·Human Brain Mapping·Prejaas TewarieArjan Hillebrand
Oct 10, 2014·Neurology·Carmen TurOlga Ciccarelli
Apr 17, 2015·IEEE Transactions on Medical Imaging·M Jorge CardosoSebastien Ourselin
Jul 16, 2015·Brain : a Journal of Neurology·Elijah MakJohn T O'Brien
Sep 4, 2015·Schizophrenia Research·Betty M TijmsStephen M Lawrie
Feb 26, 2016·Brain : a Journal of Neurology·Carmen TurAhmed T Toosy
Nov 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Benjamin A E HuntMatthew J Brookes
Apr 13, 2017·Brain Pathology·Natalia PetrovaKlaus Schmierer
Jul 21, 2017·Scientific Reports·Yulia R GelL Leticia Ramirez Ramirez
Sep 15, 2017·Annals of Clinical and Translational Neurology·Francesco GrussuClaudia A M Gandini Wheeler-Kingshott
Nov 5, 2017·Neurology·Georgina ArrambideXavier Montalban
Dec 23, 2017·Human Brain Mapping·Lester Melie-GarciaAntoine Lutti
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen

❮ Previous
Next ❯

Citations

Nov 16, 2019·Brain : a Journal of Neurology·Kim A MeijerJeroen J G Geurts
Feb 26, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Carmen TurOlga Ciccarelli
Jul 6, 2019·Therapeutic Advances in Neurological Disorders·Rosa CorteseAhmed T Toosy
Oct 22, 2019·Frontiers in Neuroscience·Etienne FortanierWafaa Zaaraoui
Apr 8, 2020·Annals of Clinical and Translational Neurology·Gabriel Gonzalez-EscamillaSergiu Groppa
Dec 18, 2020·Frontiers in Neurology·Hamza FarooqFlavia Nelson

❮ Previous
Next ❯

Software Mentioned

JIM
Stata
MATLAB
FreeSurfer
Brain Connectivity Toolbox

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.