Structural details of the glycosyltransferase step of peptidoglycan assembly

Current Opinion in Structural Biology
Andrew L LoveringNatalie C J Strynadka

Abstract

The importance of peptidoglycan in forming the basis of the bacterial cell wall has led to many studies investigating its synthesis. The step of cross-linkage via transpeptidation, and its inhibition by penicillins, has been extremely well characterized yet knowledge of the preceding glycosyltransfer reaction remained elusive until recently. The structures of two glycosyltransferase enzymes, catalyzing membrane-based polymerization of the lipid II monomer unit, have presented a means of elucidating the molecular details of this highly desirable antibiotic target. Evidence acquired before the publication of the structures is related here to these new findings, with particular emphasis on the recognition of substrates and inhibitors.

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Citations

Jun 6, 2012·Annual Review of Biochemistry·Andrew L LoveringNatalie C J Strynadka
May 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ming-Ta SungChe Ma
Apr 24, 2010·Journal of the American Chemical Society·Patrick A FrantomJohn S Blanchard
Mar 2, 2013·Journal of the American Chemical Society·Christian M GampeDaniel Kahne
Jan 20, 2016·Journal of Pharmaceutical and Biomedical Analysis·Bart BlanchaertAnn Van Schepdael
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Nov 26, 2010·Critical Reviews in Biotechnology·Ankur GautamRupinder Tewari

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Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

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