Structural determinants of antibiotic allergy

Current Allergy Reports
B A BaldoN H Pham

Abstract

Allergies to antibiotics, mainly the beta-lactam antibiotics (penicillins and cephalosporins), are a common, costly, and potentially dangerous clinical problem encountered in everyday practice. Although studies on the role of non-beta-lactam antibiotics in allergic diseases, particularly the development of specific diagnostic tests and the immunochemical identification of allergenic structures, have been too few and relatively superficial, the situation with the beta-lactam antibiotics is much more advanced. Good progress has been made in identifying the spectra of allergenic determinants recognized by IgE antibodies in the sera of subjects sensitized to penicillins and cephalosporins, and this is aiding the development of an appropriate battery of drug conjugates for use as diagnostic agents. Patient-sensitivity responses to the beta-lactam antibiotics are frequently heterogeneous, and this factor must be taken into account for any diagnostic strategy or future therapy with a penicillin or cephalosporin.

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Citations

Apr 2, 2008·Current Allergy and Asthma Reports·Brian A BaldoNghia H Pham
Jul 27, 2011·Clinical Reviews in Allergy & Immunology·Christopher ChangM Eric Gershwin
Oct 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V L Hegde, Y P Venkatesh
Aug 14, 2008·Clinical and Experimental Dermatology·A HandisuryaS Wöhrl
Jul 8, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B A BaldoN H Pham
Jul 20, 2002·Current Opinion in Allergy and Clinical Immunology·Brian A Baldo, Nghia H Pham
Mar 8, 2003·Allergy·E ScalaP Pietro

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