Structural distinctions in BMPs underlie divergent signaling in spinal neurons.

Neural Development
Jeanette C Perron, J Dodd

Abstract

In dorsal spinal neurons and monocytes, bone morphogenetic protein (BMP)7 activates distinct transduction pathways, one leading to inductive specification and the other to axon orientation and chemotaxis. BMP7-evoked induction, also stimulated by the closely related BMP6, acts through a Smad cascade, leading to nuclear signaling, and is not BMPR subunit selective. Orientation is evoked by BMP7, but not by BMP6, through PI3K-dependent cytoskeletal activation mediated by the type II BMPRs, ActRIIA and BMPRII and is independent of the Smad cascade. The responses can be stimulated concurrently and suggest that BMP7, but not BMP6, can selectively activate BMPR subunits that engage the divergent paths. Although structural and biochemical analyses of selected BMP/BMPR interfaces have identified key regions of interaction, how these translate into function by related BMPs is poorly understood. To determine the mechanisms underlying the distinct activities of BMP7 and the disparate properties of BMP7 and BMP6 in spinal cord development, we have performed a family-wide structure/function analysis of BMPs and used the information to predict and test sites within BMPs that may control agonist properties, in particular the ability of a BMP ...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N S CunninghamA H Reddi
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L GriffithW D Carlson
Dec 12, 1997·Biochimica Et Biophysica Acta·R Derynck, X H Feng
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·J Massagué
Sep 10, 2003·The Journal of Cell Biology·Victoria C FolettaJuliana Soosairaiah
Apr 6, 2004·Nature Structural & Molecular Biology·Sascha KellerThomas D Mueller
Sep 29, 2004·Biological Chemistry·Walter SebaldThomas D Mueller
May 14, 2005·Journal of Molecular Biology·Joachim NickelThomas D Mueller
Dec 13, 2005·Nature Reviews. Neuroscience·Aimin Liu, Lee A Niswander
May 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·George P AllendorphSenyon Choe
Oct 11, 2007·Biochemistry·George P AllendorphSenyon Choe
Sep 19, 2009·Journal of Biochemistry·Kohei MiyazonoMasato Morikawa
Nov 10, 2009·Cytokine & Growth Factor Reviews·Christina SieberPetra Knaus
May 21, 2010·Molecular Endocrinology·Michael J IsaacsSenyon Choe
Oct 21, 2010·Cellular Signalling·Beth BragdonAnja Nohe

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Citations

May 16, 2013·Cellular and Molecular Life Sciences : CMLS·Gwenvael Le Dréau, Elisa Martí
Feb 13, 2015·Frontiers in Cellular Neuroscience·Nelson Osses, Juan P Henríquez
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fatemeh NoroziNajmaldin Saki
May 24, 2017·Medical Teacher·Ken Masters
Feb 1, 2017·Digital Health·Btihaj Ajana
Jan 29, 2017·Cold Spring Harbor Perspectives in Biology·Emily A Meyers, John A Kessler

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Methods Mentioned

BETA
Antibody
PCR
transfection

Software Mentioned

Cn3D
AcRIIA
Vector NTI
ArboDraw
ImageJ
Genewiz

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