Structural diversity and biological activities of phloroglucinol derivatives from Hypericum species

Phytochemistry
Henrique BridiGilsane Lino von Poser

Abstract

Plants of the genus Hypericum (Hypericaceae) are used in folk medicine all over the world, H. perforatum being the most well-known species. Standardized extracts of this plant are commercially-available to treat mild to moderate depression cases. The present review summarizes the literature published up to 2016 concerning the phloroglucinol derivatives isolated from Hypericum species, together with their structural features and biological activities. These phytochemical studies led to the isolation of 101 prenylated phloroglucinols, chromanes and chromenes, 35 dimeric acylphloroglucinols, 235 polycyclic polyprenylated acylphloroglucinols, 25 simple benzophenones and 33 phloroglucinol-terpene adducts. These compounds show a diverse range of biological activities, such as antimicrobial, cytotoxic, antinociceptive and antidepressant-like effects.

References

Sep 1, 1991·Journal of Natural Products·H JayasuriyaJ D McChesney
Mar 1, 1989·Journal of Natural Products·H JayasuriyaJ M Pezzuto
Nov 1, 1995·Phytochemistry·L RochaK Hostettmann
Jul 31, 1998·Pharmacopsychiatry·S S ChatterjeeC Erdelmeier
May 29, 1999·Journal of Natural Products·L VerottaE Bombardelli
Apr 4, 2000·Phytochemistry·L H HuK Y Sim
Apr 11, 2000·Journal of Natural Products·L VerottaE Bombardelli
Feb 15, 2001·Journal of Natural Products·M D ShanZ L Chen
Jun 26, 2001·Journal of Natural Products·K WinkelmannO Sticher
Jul 17, 2001·Phytochemistry·A B FerrazG L Lino von Poser
Mar 23, 2002·Journal of Natural Products·Michiko MatsuhisaOzodbek Ashurmetov
Apr 9, 2002·Phytochemistry·Paraskev T Nedialkov, Gerassim M Kitanov
Aug 22, 2002·Journal of Agricultural and Food Chemistry·Anna Rita BiliaFranco Francesco Vincieri
Jan 25, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Walter E Müller
Mar 15, 2003·Natural Product Reports·Michael B Austin, Joseph P Noel
Jul 3, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Katarina HostanskaReinhard Saller
Aug 27, 2003·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Karin WinkelmannJörg Heilmann
Sep 27, 2003·Journal of Natural Products·Katarina Savikin-FodulovićSlobodan Milosavljević
Oct 28, 2003·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Naòma BenkikiElisabeth Seguin
May 29, 2004·Journal of Natural Products·Daylin Gamiotea-TurroLuca Rastrelli
Jun 23, 2004·Life Sciences·Tiziana Mennini, Marco Gobbi
Jun 26, 2004·Journal of Natural Products·Konstantinos AthanasasDimitris Kletsas
Dec 1, 2004·Journal of Natural Products·Naonobu TanakaOzodbek Ashurmetov
Dec 14, 2004·Chembiochem : a European Journal of Chemical Biology·Michael GartnerJonathan P Sleeman
Jan 15, 2005·Phytochemistry·Zakia BoubakirLudger Beerhues
Jan 18, 2005·Phytochemistry·Petra KlingaufLudger Beerhues
Feb 8, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A FerrazG L von Poser
Jun 1, 2005·Journal of Natural Products·Ana Paula M BernardiGilsane Lino von Poser
Jun 1, 2005·Phytochemistry·Simon GibbonsChristopher Clennett
Jul 26, 2005·Phytotherapy Research : PTR·Rodrigo Dall'agnolGilsane L von Poser
Dec 1, 2005·Phytochemical Analysis : PCA·Sara L CrockettIkhlas A Khan
Jul 29, 2006·Natural Product Reports·Inder Pal Singh, Sandip B Bharate
Sep 14, 2006·Chemical Reviews·Roxana Ciochina, Robert B Grossman
Sep 16, 2006·Phytochemistry·Ludger Beerhues
Nov 7, 2006·Phytochemistry·Ju-young LeeColin C Duke
Nov 28, 2006·Journal of Natural Products·Geneive E HenryNavindra P Seeram
Jun 1, 1992·Planta medica·P Maisenbacher, K A Kovar
Jan 20, 2007·Bioorganic & Medicinal Chemistry Letters·Luisella VerottaReto Brun

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Citations

Sep 27, 2019·Mini Reviews in Medicinal Chemistry·Mariangela MarrelliFilomena Conforti
May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara E MoghadamEhsan Jabbarzadeh
Sep 24, 2020·Angewandte Chemie·Jonathan H BoyceJohn A Porco
Dec 29, 2020·Natural Product Research·Jin-Yan XieXi-Tao Yan
Dec 31, 2020·International Journal of Molecular Sciences·Alessandro AllegraSebastiano Gangemi
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valery M DembitskyVladimir V Poroikov
Feb 24, 2020·Phytochemistry·Konstantina ZeliouFotini N Lamari
May 5, 2021·Chinese Journal of Natural Medicines·Wei-Xian LiLing-Yi Kong
May 10, 2021·Phytochemistry·Katarína BruňákováEva Čellárová
Jun 19, 2021·Journal of Natural Medicines·Kanji NiwaYoshiki Kashiwada
Aug 14, 2021·Planta medica·Maria-Eleni GrafakouHelen Skaltsa
May 3, 2019·Journal of Natural Products·Xin-Wen ZhangGang Xu
Oct 10, 2019·Journal of Natural Products·Kanji NiwaYoshiki Kashiwada
Oct 21, 2019·Fitoterapia·Gabriela de Carvalho MeirellesMarina Cardoso Nemitz
Jan 31, 2020·Organic Letters·Van-Tuan VuJian-Guang Luo
Mar 29, 2019·Journal of Natural Products·María Goretti Arvizu-EspinosaAlexandre Cardoso-Taketa

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