Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids.

Natural Product Reports
Yong ShenDa-Ke Zhao

Abstract

Covering: 2009 to 2018. Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, are a diverse class of compounds having complex structural features with many stereocenters. The important pharmacological activities and structural complexity of the diterpenoid alkaloids have long interested scientists due to their medicinal uses, infamous toxicity, and unique biosynthesis. Since 2009, 373 diterpenoid alkaloids, assigned to 46 skeletons, have been isolated and identified from plants mostly in the Ranunculaceae family. The names, classes, molecular weight, molecular formula, NMR data, and plant sources of these diterpene alkaloids are collated here. This review will be a detailed update of the naturally occurring diterpene alkaloids reported from the plant kingdom from 2009-2018, providing an in-depth discussion of their diversity, biological activities, pharmacokinetics, toxicity, application, evolution, and biosynthesis.

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Citations

Jul 28, 2020·Natural Product Reports·Grace J DrummondMargaret A Brimble
Mar 22, 2021·Bioorganic & Medicinal Chemistry·Yali WangLixia Chen
Apr 24, 2021·Frontiers in Plant Science·Chaiwat AneklaphakijTakayuki Tohge
May 4, 2021·Journal of the American Chemical Society·Quanzheng ZhangMin Zhang
May 13, 2021·Natural Products and Bioprospecting·Hao-Yi LiPema-Tenzin Puno
Jul 17, 2021·Phytochemistry·Jin-Bu XuXian-Li Zhou

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Methods Mentioned

BETA
NMR
X-ray
glycosidation
MDAs

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