Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip

Arthritis and Rheumatism
Michel LequesneRenèe-Liliane Dreiser

Abstract

To evaluate the structural effect of avocado/soybean unsaponifiables (ASU) in the treatment of patients with symptomatic osteoarthritis (OA) of the hip. Patients with regular painful primary OA of the hip (European League Against Rheumatism 1980 criteria) and a joint space still > or = 1 mm (Kellgren grade 1 to 3, assessed by an independent observer prior to inclusion) entered a prospective, multicenter, randomized, parallel group, double-blind, placebo-controlled trial of 2 years duration. Patients had at least a 6-month history of regular pain and an algofunctional index (AFI) > or = 4. The primary assessment criterion was a decrease of the joint space width (JSW) on plain anteroposterior radiographs of the pelvis performed in standing position, measured at the narrowest points by 2 independent readers, previously tested and selected and blinded to both the treatment and the time sequence. Secondary criteria were standard clinical outcome measurements (AFI, pain on a visual analog scale, consumption of nonsteroidal antiinflammatory drugs and patient's and investigator's global assessments). One hundred sixty-three patients were included: 102 men and 61 women (mean age 63.2 +/- 8.7 years). A total of 108 patients (72 men and 3...Continue Reading

References

Jul 1, 1978·Radiology·T G ArmbusterL A Danzig
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·M G LequesneP Gerard
Nov 1, 1987·Arthritis and Rheumatism·R D AltmanW A Murphy
Nov 9, 1974·Lancet·E C Huskisson
Mar 1, 1995·Current Opinion in Rheumatology·M Dougados
Jan 1, 1997·Osteoarthritis and Cartilage·T ConrozierE Vignon
Jun 12, 1999·Annals of the Rheumatic Diseases·P ReisB Amor
Jul 27, 1999·Osteoarthritis and Cartilage· Buckland-Wright
Jan 13, 2001·Osteoarthritis and Cartilage·M G Lequesne, E Maheu
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE

❮ Previous
Next ❯

Citations

Sep 29, 2012·Drugs & Aging·Ryan L Ragle, Allen D Sawitzke
Dec 11, 2013·International Wound Journal·Ahmad OryanMohammad R Tabandeh
May 23, 2014·The Cochrane Database of Systematic Reviews·Melainie Cameron, Sigrun Chrubasik
Sep 21, 2018·Current Rheumatology Reports·Yves Henrotin, Ali Mobasheri
Jan 17, 2020·Biomolecules·Bahare SalehiNatália Martins
May 17, 2003·Drugs & Aging·Karen Walker-Bone
Feb 9, 2007·The Tohoku Journal of Experimental Medicine·Levent AltinelMustafa Serteser
Oct 27, 2009·Phytotherapy Research : PTR·Melainie CameronSigrun Chrubasik
Jan 1, 2009·Revista Brasileira De Ortopedia·Márcia Uchôa de Rezende, Riccardo Gomes Gobbi
Sep 27, 2019·Antioxidants·Deep Jyoti BhuyanKonstantinos Papoutsis
Mar 12, 2005·Current Rheumatology Reports·Roland W Moskowitz, Michele Hooper
Nov 17, 2010·Nature Reviews. Rheumatology·David J Hunter
Feb 16, 2013·Expert Opinion on Investigational Drugs·Peter S E DaviesEleftherios Tsiridis
Jan 6, 2016·Nutrition Journal·Ashok Kumar Grover, Sue E Samson
Jan 27, 2015·Cartilage·Blaine A ChristiansenShahin Emami
Feb 28, 2014·The Proceedings of the Nutrition Society·Jonathan A GreenIan M Clark
Apr 16, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Courtney BoydUNKNOWN HERB Working Group
Apr 18, 2007·Current Rheumatology Reports·Tracy M Frech, Daniel O Clegg
Jun 5, 2007·American Journal of Veterinary Research·Christopher E KawcakRichard D Park
Nov 10, 2005·Rheumatology·G Verbruggen
Dec 21, 2010·Rheumatology·Vijitha De SilvaUNKNOWN Arthritis Research UK Working Group on Complementary and Alternative Medicines
May 4, 2013·Critical Reviews in Food Science and Nutrition·Mark L Dreher, Adrienne J Davenport
Apr 9, 2017·Annals of the Rheumatic Diseases·Garifallia SakellariouAnnamaria Iagnocco
Mar 6, 2009·Geriatrics & Gerontology International·Motoo KikuchiRyuzo Ueda
Mar 12, 2005·Current Rheumatology Reports·Maxime Dougados
Nov 7, 2006·The Veterinary Clinics of North America. Small Animal Practice·Steven C Budsberg, Joseph W Bartges
Aug 9, 2008·Rheumatic Diseases Clinics of North America·David J Hunter, Marie-Pierre Hellio Le Graverand-Gastineau
Dec 9, 2008·The Medical Clinics of North America·David J Hunter, Marie-Pierre Hellio Le Graverand-Gastineau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.