Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice

Carbohydrate Polymers
Pei HuChenggang Huang

Abstract

A fucoidan, Sargassum fusiforme polysaccharide 65 (SFPS65) A, was isolated from a brown alga (S. fusiforme). SFPS65A had an estimated molecular weight of 90kDa and showed αD(20) -74.3288 (c 0.05, H2O). SFPS65A is composed of fucose, galactose, xylose, glucose, glucuronic acid, and mannose in the ratio of 19.23:9.58:6.64:1:6.52:2.57. The structural features of SFPS65A were investigated using composition analysis, methylation analysis, infrared spectrum, nuclear magnetic resonance spectroscopy, and electrospray ionization quadruple time-of-flight tandem mass spectroscopy. Results showed that SFPS65A has a main chain composed of →3)-β-l-Fucp-(1→3,4)-β-l-Fucp-(1→3,4)-β-l-Fucp-(1→ and connected with →3,4)-α-d-GlcAp-(1→, →4)-β-d-Xylp-(1→, →4)-α-d-Galp-(1→, →3,6)-α-d-Manp-(1→ alternately. The branches at O-3 of the fucosyl residue and O-3 of the hexosyl residues may include sulfate, →4)-β-l-Fucp-(1→, β-d-Xylp-(1→, and β-d-Xylp-(1→. SFPS65A exhibited an activity on Alzheimer's disease in vivo in the pharmacological experiments by increasing the cognitive abilities of scopolamine-, ethanol-, and sodium nitrite-treated mice against memory deficits.

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Citations

Nov 5, 2016·International Journal of Biological Macromolecules·Xiaomeng YuXiaolu Jiang
Aug 9, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chiara Fabbri, Alessandro Serretti
Nov 14, 2019·Neural Regeneration Research·Melissa SchepersTim Vanmierlo
Jul 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Faiez HentatiPhilippe Michaud
Dec 17, 2020·Frontiers in Plant Science·Nora M A Ponce, Carlos A Stortz
Dec 29, 2020·Mitochondrial DNA. Part B, Resources·Tao LiuMingjiang Wu
Nov 3, 2020·Food Science & Nutrition·Jian LiuHaibin Tong
Mar 4, 2021·Marine Drugs·Leonel Pereira, Ana Valado
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuhao SunPengcheng Li
Jun 15, 2021·International Journal of Biological Macromolecules·Yi-Meng LiZhi-Gang Luo
Aug 8, 2021·Foods·Maria Dyah Nur MeinitaJae-Suk Choi

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