Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples

Scientific Reports
Vanderson S BispoMarisa Medeiros

Abstract

Aldehydes accumulate in inflammation, during myocardial infarction and have been associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and acrolein was characterized using extensive spectroscopic measurements. The adduct with urinary concentrations of 1.82 ± 0.68 nmol/mg of creatinine is one of the most abundant acrolein metabolites in urine and opens promising therapeutic strategies for carnosine.

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Citations

Jun 28, 2016·Maturitas·Alan R HipkissBarbora de Courten
Mar 6, 2018·European Journal of Sport Science·Guilherme Giannini ArtioliRebecca Louise Jones
Sep 19, 2018·The Journal of Clinical Investigation·Ethan J AndersonGiancarlo Aldini
Mar 9, 2019·Recent Patents on Drug Delivery & Formulation·Sergei V Jargin
Oct 11, 2017·Current Pharmacology Reports·Sean S Davies, Linda S Zhang
Aug 1, 2019·Current Medicinal Chemistry·Katarzyna Kilis-Pstrusinska
Jul 28, 2018·Redox Biology·Victor H CarvalhoMarisa H G Medeiros
Aug 14, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Mark D TurnerAlan R Hipkiss

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Methods Mentioned

BETA
NMR

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