Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Ines ValentaThomas H Schindler

Abstract

The aim of this study was to determine whether epicardial structural disease may affect the manifestation of a longitudinal decrease in myocardial blood flow (MBF) or MBF difference during hyperemia in cardiovascular risk individuals, and its dependency on the flow increase. In 54 cardiovascular risk individuals (at risk) and in 26 healthy controls, MBF was measured with (13)N-ammonia and PET/CT in mL/g/min at rest and during dipyridamole stimulation. Computed tomography coronary angiography (CTA) was performed using a 64-slice CT of a PET/CT system. Absolute MBFs during dipyridamole stimulation were mildly lower in the mid-distal than in the mid-LV myocardium in controls (2.20 ± .51 vs 2.29 ± .51, P < .0001), while it was more pronounced in at risk with normal and abnormal CTA (1.56 ± .42 vs 1.91 ± .46 and 1.18 ± .34 vs 1.51 ± .40 mL/g/min, respectively, P < .0001), resulting in a longitudinal MBF difference that was highest in at risk with normal CTA, intermediate in at risk abnormal CTA, and lowest in controls (.35 ± .16 and .22 ± .09 vs .09 ± .04 mL/g/min, respectively, P < .0001). On multivariate analysis, log-CCS and mid-LV hyperemic MBF increase, indicative of microvascular function, were independent predictors of the ob...Continue Reading

References

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Citations

Nov 26, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Masanao NayaHiroyuki Tsutsui
Feb 25, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ines ValentaThomas H Schindler
May 1, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gabriella M VincentiThomas H Schindler
Jun 21, 2014·Seminars in Nuclear Medicine·Thomas H SchindlerVasken Dilsizian
Dec 30, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Thomas Hellmut Schindler
Mar 19, 2014·JACC. Cardiovascular Imaging·Ines ValentaThomas H Schindler
Dec 22, 2012·Mediators of Inflammation·Alessandra QuercioliNicolas Vuilleumier
Jun 24, 2015·PET Clinics·Thomas Hellmut Schindler
Feb 1, 2015·Progress in Cardiovascular Diseases·Thomas H Schindler
Nov 25, 2014·Current Cardiology Reports·Ines ValentaThomas H Schindler
Jun 22, 2016·European Heart Journal Cardiovascular Imaging·Ines ValentaThomas H Schindler
Sep 7, 2016·Diagnostics·Jonathan A Pan, Michael Salerno
Jan 23, 2017·JACC. Cardiovascular Imaging·Matthew J KruseThomas H Schindler
Jan 19, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Habib Zaidi, Rene Nkoulou
Mar 1, 2019·Current Cardiology Reports·Matthieu Pelletier-GalarneauGeorges El Fakhri
Jun 24, 2017·BioMed Research International·Jinhui LiYou Zhou
Aug 5, 2017·Frontiers in Cardiovascular Medicine·Thorsten M LeuckerThomas Hellmut Schindler
Dec 16, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Venkatesh L MurthyJames R Corbett
Dec 16, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Venkatesh L MurthyUNKNOWN ASNC Board of Directors

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