Structural features of mono- and tri-nuclear Zn(II) complexes with a non-steroidal anti-inflammatory drug as ligand

Dalton Transactions : an International Journal of Inorganic Chemistry
Alketa TarushiDimitris P Kessissoglou

Abstract

The interaction of Zn(II) with the non-steroidal anti-inflammatory drug tolfenamic acid leads to the formation of the structurally characterized trinuclear [Zn(3)(tolfenamato)(6)(CH(3)OH)(2)] complex. In the presence of the N,N'-donor heterocyclic ligands 1,10-phenanthroline and 2,2'-bipyridine at a range of ratios, the mononuclear Zn complexes of the general formulae [Zn(tolfenamato)(N,N'-donor)Cl] and [Zn(tolfenamato)(2)(N,N'-donor)] have been isolated and structurally characterized by X-ray crystallography. The deprotonated tolfenamato ligands are coordinated to the Zn(II) ion through carboxylato oxygen atoms. Tolfenamic acid and its complexes exhibit good binding propensity to human or bovine serum albumin protein having relatively high binding constant values.

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Mar 17, 2010·Bioorganic & Medicinal Chemistry·Alketa TarushiDimitris P Kessissoglou
Apr 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Filitsa DimizaGeorge Psomas
Aug 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Filitsa DimizaGeorge Psomas
Aug 20, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Alketa TarushiDimitris P Kessissoglou
Dec 31, 2011·European Journal of Medicinal Chemistry·Sofia TsiliouGeorge Psomas

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Citations

Jul 5, 2012·Inorganic Chemistry·Alketa TarushiDimitris P Kessissoglou
Aug 21, 2013·Journal of Inorganic Biochemistry·Alketa TarushiDimitris P Kessissoglou
Mar 27, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·George Psomas, Dimitris P Kessissoglou
Jun 16, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Ying XiaoHui Li
Aug 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel EjarqueJosefina Pons
Jan 29, 2019·Nucleosides, Nucleotides & Nucleic Acids·Farhad AhmadiHoma Azizian
Mar 16, 2021·Journal of Inorganic Biochemistry·Filitsa DimizaGeorge Psomas
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Melyssa L GrieveBrett M Paterson

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