PMID: 2486374Nov 1, 1989Paper

Structural finite deformation model of the left ventricle during diastole and systole

Journal of Biomechanical Engineering
E Nevo, Y Lanir

Abstract

A model of left ventricular function is developed based on morphological characteristics of the myocardial tissue. The passive response of the three-dimensional collagen network and the active contribution of the muscle fibers are integrated to yield the overall response of the left ventricle which is considered to be a thick wall cylinder. The deformation field and the distributions of stress and pressure are determined at each point in the cardiac cycle by numerically solving three equations of equilibrium. Simulated results in terms of the ventricular deformation during ejection and isovolumic cycles are shown to be in good qualitative agreement with experimental data. It is shown that the collagen network in the heart has considerable effect on the pressure-volume loops. The particular pattern of spatial orientation of the collagen determines the ventricular recoil properties in early diastole. The material properties (myocardial stiffness and contractility) are shown to affect both the pressure-volume loop and the deformation pattern of the ventricle. The results indicate that microstructural consideration offer a realistic representation of the left ventricle mechanics.

Citations

Jan 1, 1992·Annals of Biomedical Engineering·H AzhariR Beyar
Jan 6, 2009·Biomechanics and Modeling in Mechanobiology·L CardamoneJ D Humphrey
Apr 23, 2013·Medical & Biological Engineering & Computing·Ghassan S KassabYoram Lanir
Mar 17, 2009·Bulletin of Mathematical Biology·Anna GrosbergArash Kheradvar
May 1, 1996·Journal of Biomechanics·M AbovskyE Nevo
Jun 1, 1996·Journal of Biomechanics·L A TaberW W Podszus
Dec 4, 2003·Medical Engineering & Physics·Alberto RedaelliFranco Maria Montevecchi
Oct 17, 2009·Journal of Biomechanical Engineering·A Valentín, J D Humphrey
Feb 10, 2011·Journal of Biomechanical Engineering·Yaniv HollanderYoram Lanir
Jul 13, 2011·Journal of Biomechanical Engineering·Yaniv HollanderYoram Lanir
Nov 8, 2013·Annals of Biomedical Engineering·C BelliniJ D Humphrey
Feb 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·P Foëx, B J Leone
Apr 2, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Yoram Lanir, Ravi Namani
Nov 1, 1996·Journal of Biomechanical Engineering·A Redaelli, F M Montevecchi
Nov 1, 1994·Circulation Research·L A TaberB B Keller
Dec 3, 2008·Journal of Biomechanical Engineering·J JacobsY Lanir
May 26, 2017·Biomechanics and Modeling in Mechanobiology·S Jamaleddin Mousavi, Stéphane Avril
Mar 1, 1996·Basic Research in Cardiology·D A MacKennaJ W Covell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.