Structural genomics of protein phosphatases.

Journal of Structural and Functional Genomics
Steven C AlmoStephen K Burley

Abstract

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

References

Oct 25, 1990·Nucleic Acids Research·T D Schneider, R M Stephens
Jul 1, 1989·The Journal of Cell Biology·H W Davidson, C Watts
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J L CordenM E Dahmus
Jan 1, 1986·Annual Review of Biochemistry·T D Pollard, J A Cooper
Oct 1, 1993·The Journal of Experimental Medicine·C Watts, A Lanzavecchia
Jan 1, 1995·Annual Review of Cell and Developmental Biology·D A Schafer, J A Cooper
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·M S LanA L Notkins
Aug 9, 1996·The Journal of Biological Chemistry·M E Dahmus
Feb 1, 1996·Current Opinion in Cell Biology·S H Zigmond
Oct 14, 1996·Biochemical and Biophysical Research Communications·G MagistrelliA Isacchi
Oct 1, 1996·Diabetologia·S GenoveseE Bonifacio
Nov 29, 1996·Science·S B ShukerS W Fesik
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y A PuiusZ Y Zhang
Mar 24, 1999·Trends in Biochemical Sciences·C J Jeffery
Oct 4, 2000·Nature Structural Biology·A J Shatkin, J L Manley
Jun 13, 2001·BMC Cell Biology·L G TertoolenJ den Hertog
Mar 8, 2002·Journal of Medicinal Chemistry·Adam McCluskeyJennette A Sakoff
Sep 6, 2002·The Journal of Biological Chemistry·Hye-Yeon KimKwang Yeon Hwang
Oct 12, 2002·The Journal of Biological Chemistry·Christophe BlanchetotJeroen den Hertog
Jan 28, 2003·The Journal of Biological Chemistry·Jin-Peng SunZhong-Yin Zhang
Apr 16, 2003·Annals of Medicine·Constance J Jeffery
Oct 3, 2003·The Journal of Biological Chemistry·Young Min JangOh-Shin Kwon

❮ Previous
Next ❯

Citations

Feb 17, 2009·Journal of Structural and Functional Genomics·Ursula PieperAndrej Sali
Sep 8, 2012·Molecular Neurobiology·Pham Ngoc Chien, Seong Eon Ryu
Jul 7, 2009·Nature Chemical Biology·Gabriela MolinaMichael Tsang
Aug 25, 2012·Nature Reviews. Cancer·Karen Block, Yves Gorin
Oct 23, 2012·The Journal of Biological Chemistry·Huaiyu Sun, Tony Hunter
Oct 6, 2010·Antioxidants & Redox Signaling·John J TannerKent S Gates
Sep 21, 2011·Briefings in Functional Genomics·Dina R Weilhammer, Amy Rasley
Sep 23, 2009·Acta Crystallographica. Section D, Biological Crystallography·George T LountosDavid S Waugh
May 6, 2011·Acta Crystallographica. Section D, Biological Crystallography·George T LountosDavid S Waugh
Jul 29, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Kevin KishSteven Sheriff
Jun 6, 2009·Annual Review of Biochemistry·Aled Edwards
Nov 9, 2012·Cell Communication and Signaling : CCS·Tomonori KanekoShawn Sc Li
Dec 4, 2013·Antioxidants & Redox Signaling·Stephanie M StanfordNunzio Bottini
Nov 12, 2013·Antioxidants & Redox Signaling·Lalima Gagan Ahuja, Balasubramanian Gopal
Sep 25, 2012·Expert Opinion on Drug Discovery·Sandhya Kortagere
Oct 21, 2009·The Journal of Physiology·Valerie P WrightThomas L Clanton
Oct 13, 2009·Trends in Biochemical Sciences·Matthew S GentryCarolyn A Worby
Feb 27, 2008·The Plant Journal : for Cell and Molecular Biology·Danièle MoesErwin Grill
May 12, 2009·Immunological Reviews·Kausik ChattopadhyaySteven C Almo
Feb 22, 2012·The FEBS Journal·Lan K NguyenBoris N Kholodenko
May 23, 2012·The FEBS Journal·Annegrit SeifriedAntje Gohla
Dec 25, 2012·BMB Reports·Seung Jun Kim, Seong Eon Ryu
Jul 3, 2010·Molecular and Biochemical Parasitology·Balázs Szöör
Jan 31, 2012·Chemistry & Biology·W Armand GuiguemdeR Kiplin Guy
Sep 23, 2014·Seminars in Cell & Developmental Biology·Charlotte H ColesA Radu Aricescu
Mar 5, 2016·The FEBS Journal·David A MeekinsMatthew S Gentry
Oct 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ifedayo Victor Ogungbe, William N Setzer
Feb 18, 2014·Acta Crystallographica. Section D, Biological Crystallography·Dae Gwin JeongSeong Eon Ryu
Dec 19, 2014·Chembiochem : a European Journal of Chemical Biology·Aleksandar BijelicAnnette Rompel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Related Papers

Annual Review of Biophysics and Biomolecular Structure
D BarfordM P Egloff
Protein Science : a Publication of the Protein Society
Peer BorkJ Schultz
Acta Crystallographica. Section D, Biological Crystallography
Evgeny Krissinel, Kim Henrick
© 2022 Meta ULC. All rights reserved