Structural insights for HIV-1 therapeutic strategies targeting Vif

Trends in Biochemical Sciences
Jason D SalterHarold C Smith


HIV-1 viral infectivity factor (Vif) is a viral accessory protein that is required for HIV-1 infection due largely to its role in recruiting antiretroviral factors of the APOBEC3 (apolipoprotein B editing catalytic subunit-like 3) family to an E3 ubiquitin ligase complex for polyubiquitylation and proteasomal degradation. The crystal structure of the (near) full-length Vif protein in complex with Elongin (Elo)B/C, core-binding factor (CBF)β and Cullin (Cul)5 revealed that Vif has a novel structural fold. In our opinion the structural data revealed not only the protein-protein interaction sites that determine Vif stability and interaction with cellular proteins, but also motifs driving Vif homodimerization, which are essential in Vif functionality and HIV-1 infection. Vif-mediated protein-protein interactions are excellent targets for a new class of antiretroviral therapeutics to combat AIDS.


Aug 20, 1987·Nature·Klaus StrebelM A Martin
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bärbel SchröfelbauerNathaniel R Landau
Jun 25, 2004·Nucleic Acids Research·Stephen R ComeauCarlos J Camacho
Nov 23, 2005·Bioinformatics·Konstantin ArnoldTorsten Schwede
Aug 26, 2006·Proteins·Dima KozakovSandor Vajda
Mar 14, 2008·Current HIV Research·Pierre BarraudCarine Tisné
May 24, 2008·Virology·John P DonahueRichard T D'Aquila
Jul 8, 2008·Microbes and Infection·Tomoki YamashitaMasako Nomaguchi
Jul 16, 2008·Journal of Molecular Biology·Zhiwen HeXiao-Fang Yu
Nov 7, 2008·Journal of Virology·Rebecca S LaRueReuben S Harris
Jul 11, 2009·Biochemistry·Kalyan GiriErnest L Maynard
Sep 3, 2010·Amino Acids·Daniela GalleranoRudolf Valenta
Oct 26, 2010·The Journal of Biological Chemistry·John S AlbinReuben S Harris
Jul 19, 2011·Journal of Molecular Biology·Sean R MarcsisinJohn R Engen
Mar 1, 2012·Biochemistry·Stephen M TechtmannErnest L Maynard
Sep 25, 2012·Nature Structural & Molecular Biology·Shingo KitamuraYasumasa Iwatani
Apr 12, 2013·Journal of Virology·Julien BatisseJean-Christophe Paillart
Nov 5, 2013·Nature Communications·Karen K SiuJeffrey E Lee
Mar 25, 2014·Structure·Halil AydinJeffrey E Lee


Dec 3, 2015·Cell Reports·Michael LetkoMarcel Ooms
Mar 3, 2015·Reviews in Medical Virology·Daniele FocosiMauro Pistello
Apr 8, 2015·European Journal of Medicinal Chemistry·Ting PanChuan Bai
Mar 31, 2015·Virology·Reuben S Harris, Jaquelin P Dudley
Jun 11, 2016·Trends in Biochemical Sciences·Jason D SalterHarold C Smith
Jul 12, 2016·Chemical Society Reviews·Shaoyong LuRuth Nussinov
Sep 2, 2016·Chemical Reviews·Sachini U SiriwardenaAshok S Bhagwat
Dec 7, 2017·International Reviews of Immunology·Faezeh BorzooeeMani Larijani
Mar 13, 2015·Journal of Virology·Ailie Marx, Akram Alian
Oct 21, 2016·The Journal of Biological Chemistry·Yusuke MatsuiAkifumi Takaori-Kondo
Apr 13, 2018·Viruses·Zeli ZhangCarsten Münk
Jan 21, 2016·Proteomes·Haitham Sobhy
Sep 14, 2019·Protein Science : a Publication of the Protein Society·Farshad C Azimi, Jeffrey E Lee

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