Structural insights into DNA loop extrusion by SMC protein complexes.

Current Opinion in Structural Biology
Sumanjit DattaChristian H Haering

Abstract

Structural Maintenance of Chromosomes (SMC) protein complexes play key roles in the three-dimensional organization of genomes in all kingdoms of life. Recent insights from chromosome contact mapping experiments and single-molecule imaging assays suggest that these complexes achieve distinct cellular functions by extruding large loops of DNA while they move along the chromatin fiber. In this short review, we summarize recent insights into the molecular architecture of these unconventional DNA motor complexes, their interaction with their DNA substrates, and the remarkable dynamic changes they can undergo during their ATPase reaction cycle.

References

Oct 2, 2004·Current Biology : CB·Alfred LammensKarl-Peter Hopfner
May 20, 2014·Nature Structural & Molecular Biology·Ilaria PiazzaChristian H Haering
Aug 31, 2014·FEBS Letters·Maurici B RoigKim Nasmyth
Oct 29, 2014·The EMBO Journal·Anna RojowskaKarl-Peter Hopfner
Jan 6, 2015·Molecular Cell·Young-Min SohStephan Gruber
Oct 27, 2015·Proceedings of the National Academy of Sciences of the United States of America·Adrian L SanbornErez Lieberman Aiden
Nov 4, 2015·Molecular Cell·Elzo de WitWouter de Laat
Feb 21, 2016·The EMBO Journal·Florian Ulrich SeifertKarl-Peter Hopfner
Feb 26, 2016·Cell Reports·Jorine M EeftensCees Dekker
May 19, 2016·ELife·Anton GoloborodkoLeonid Mirny
May 24, 2016·Cell Reports·Geoffrey FudenbergLeonid A Mirny
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sotaro KikuchiHongtao Yu
Jan 11, 2017·Current Biology : CB·Jonathan N WellsJoseph A Marsh
Jan 31, 2017·Nature Communications·Aaron AltAntony W Oliver
Feb 28, 2017·Molecular Cell·Frank BürmannStephan Gruber
May 23, 2017·Molecular Cell·Hideharu HashimotoXiaodong Cheng
Jul 12, 2017·Molecular Cell·Marie-Laure Diebold-DurandStephan Gruber
Sep 9, 2017·Science·Tsuyoshi TerakawaEric C Greene
Jan 20, 2018·Science·Johan H GibcusJob Dekker
Feb 24, 2018·Science·Mahipal GanjiCees Dekker
Oct 27, 2018·Current Genetics·Matthew Robert PaulSevinç Ercan
Nov 7, 2018·Current Biology : CB·Markus HasslerChristian H Haering
Dec 14, 2018·Current Opinion in Cell Biology·Tomoko Nishiyama
Mar 6, 2019·Nature Structural & Molecular Biology·Frank BürmannJan Löwe
Mar 13, 2019·EMBO Reports·Kodai HaraHiroshi Hashimoto
May 21, 2019·Current Opinion in Genetics & Development·Ángela Sedeño Cacciatore, Benjamin D Rowland
Jun 16, 2019·Molecular Cell·Christophe ChapardKim Nasmyth
Jun 16, 2019·Molecular Cell·Roberto Vazquez NunezStephan Gruber
Jun 22, 2019·Molecular Cell·Markus HasslerChristian H Haering
Jul 28, 2019·The Journal of Biological Chemistry·Karen Manalastas-CantosDmitri I Svergun

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Citations

Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shunsuke TakahashiShinji Katsura
Apr 4, 2021·International Journal of Molecular Sciences·Ana BoavidaFrancesca M Pisani
Apr 11, 2021·Seminars in Cell & Developmental Biology·James R PaulsonWilliam C Earnshaw

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