Structural Insights into High Density Lipoprotein: Old Models and New Facts

Frontiers in Pharmacology
Valentin Gogonea

Abstract

The physiological link between circulating high density lipoprotein (HDL) levels and cardiovascular disease is well-documented, albeit its intricacies are not well-understood. An improved appreciation of HDL function and overall role in vascular health and disease requires at its foundation a better understanding of the lipoprotein's molecular structure, its formation, and its process of maturation through interactions with various plasma enzymes and cell receptors that intervene along the pathway of reverse cholesterol transport. This review focuses on summarizing recent developments in the field of lipid free apoA-I and HDL structure, with emphasis on new insights revealed by newly published nascent and spherical HDL models constructed by combining low resolution structures obtained from small angle neutron scattering (SANS) with contrast variation and geometrical constraints derived from hydrogen-deuterium exchange (HDX), crosslinking mass spectrometry, electron microscopy, Förster resonance energy transfer, and electron spin resonance. Recently published low resolution structures of nascent and spherical HDL obtained from SANS with contrast variation and isotopic labeling of apolipoprotein A-I (apoA-I) will be critically re...Continue Reading

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Citations

Aug 17, 2016·Biochemistry·Chase A Brisbois, Jennifer C Lee
Mar 11, 2017·Atherosclerosis·Chaoye GanYong Chen
May 19, 2018·Journal of Lipid Research·Allison L CookeW Sean Davidson
Dec 19, 2018·Journal of Lipid Research·Alexander McPherson, Steven B Larson
Feb 6, 2020·Current Opinion in Lipidology·Paolo Zanoni, Arnold von Eckardstein
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Jan 14, 2021·Journal of Structural Biology: X·Chris J MalajczukRicardo L Mancera
Aug 21, 2021·Proteins·Romina A GisonnoM Alejandra Tricerri

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Methods Mentioned

BETA
SANS
lipidation
differential scanning calorimetry
fluorescence spectroscopy
circular
size exclusion chromatography
infrared spectroscopy
small angle neutron scattering
atomic force microscopy
phosphotransferase

Software Mentioned

SAS
CHARMM24
nHDL
CHARMM

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