Structural insights into RNA splicing

Current Opinion in Structural Biology
Navtej ToorAnna Marie Pyle


Intron splicing is a fundamental biological process whereby noncoding sequences are removed from precursor RNAs. Recent work has provided new insights into the structural features and reaction mechanisms of two introns that catalyze their own splicing from precursor RNA: the group I and II introns. In addition, there is an increasing amount of structural information on the spliceosome, which is a ribonucleoprotein machine that catalyzes nuclear pre-mRNA splicing in eukaryotes. Here, we compare structures and catalytic mechanisms of self-splicing RNAs and we discuss the possible implications for spliceosomal reaction mechanisms.


Dec 1, 1990·Genes & Development·H D MadhaniC Guthrie
Jan 31, 1986·Cell·C L PeeblesH L Cheng
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Thomas A Steitz, J A Steitz
Apr 11, 2001·The EMBO Journal·J SwisherAnna Marie Pyle
Jun 5, 2003·Molecular Biology and Evolution·Joshua S Rest, David P Mindell
Jan 28, 2004·Nature Structural & Molecular Biology·Roland K O SigelAnna Marie Pyle
May 18, 2004·RNA·Angela K Hilliker, Jonathan P Staley
Jun 4, 2004·Nature·Peter L AdamsScott A Strobel
Nov 16, 2004·Nature Structural & Molecular Biology·Dipali G SashitalSamuel E Butcher
Dec 8, 2004·Nature Structural & Molecular Biology·Barbara L GoldenElaine Chase
Jun 28, 2005·Nature Structural & Molecular Biology·Alexandre de LencastreAnna Marie Pyle
Sep 6, 2005·Science·Mary R Stahley, Scott A Strobel
Dec 17, 2005·Trends in Biochemical Sciences·Quentin Vicens, T R Cech
May 16, 2006·Current Opinion in Structural Biology·Mary R Stahley, Scott A Strobel
Jan 11, 2007·Chemical Reviews·Roland K O Sigel, Anna Marie Pyle
Feb 10, 2007·Trends in Biochemical Sciences·Anna Marie PyleChristina Waldsich
Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Aaron R RobartSteven Zimmerly
Jun 23, 2007·Chemistry & Biology·Peter M GordonJoseph A Piccirilli
Apr 5, 2008·Science·Navtej ToorAnna Marie Pyle
Apr 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah V Lipchock, Scott A Strobel
Sep 9, 2008·Journal of Molecular Biology·Kevin S KeatingAnna Marie Pyle
Oct 7, 2008·Nature Structural & Molecular Biology·Dustin B RitchieAndrew M Macmillan
Oct 10, 2008·The EMBO Journal·Vladimir PenaMarkus C Wahl
Oct 28, 2008·Nature Structural & Molecular Biology·Navtej ToorAnna Marie Pyle
Dec 4, 2008·Nature Structural & Molecular Biology·J Abelson


Oct 25, 2013·Nucleic Acids Research·Zing Tsung-Yeh TsaiHuai-Kuang Tsai
Dec 15, 2010·Pathology Research International·Lawrence M Agius
Sep 18, 2010·Cellular and Molecular Life Sciences : CMLS·Jessica Jacobs, Ulrich Kück
Sep 22, 2010·Quarterly Reviews of Biophysics·Wei Yang
Mar 8, 2013·Journal of Molecular Biology·Irina V NovikovaKarissa Y Sanbonmatsu
Aug 14, 2010·European Journal of Cell Biology·Jessica JacobsUlrich Kück
Oct 5, 2013·Science China. Life Sciences·Juanjuan ZhuXiaofei Zheng
Jul 20, 2010·Computational Biology and Chemistry·Olfa SialaFaiza Fakhfakh
Apr 29, 2014·Biochimica Et Biophysica Acta·Arati Ramesh, Wade C Winkler
Nov 30, 2010·Protein Expression and Purification·Patrick K ArthurT Kwaku Dayie
Jul 1, 2015·Journal of the American Chemical Society·Selene C KooJoseph A Piccirilli
Aug 1, 2011·Biomolecular Concepts·Xin Qi, Tianbing Xia
Apr 29, 2011·RNA Biology·Fabian A BuskeTimothy L Bailey
Feb 18, 2011·Nucleus·Jennifer C HofmannOliver J Gruss
Oct 16, 2012·RNA Biology·Nora Sachsenmaier, Christina Waldsich
Apr 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ki-Young Lee, Bong-Jin Lee
Jan 24, 2014·Nature Reviews. Molecular Cell Biology·A Gregory Matera, Zefeng Wang
May 8, 2010·Critical Reviews in Biochemistry and Molecular Biology·Anna Marie Pyle
Nov 6, 2013·Acta Crystallographica. Section D, Biological Crystallography·Marco MarciaAnna Marie Pyle
Oct 25, 2011·Angewandte Chemie·Kazuhiro FurukawaYoshihiro Ito
Nov 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Bishnu P PaudelDavid S Rueda
Mar 23, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Tengchuan JinYuzhu Zhang
Jul 16, 2017·Biophysical Chemistry·Neil A White, Charles G Hoogstraten
Apr 21, 2021·Chembiochem : a European Journal of Chemical Biology·Yuki MoriYoshiya Ikawa

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