Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus.

Proceedings of the National Academy of Sciences of the United States of America
James A GarnettSteve Matthews

Abstract

Bacteria have evolved a variety of mechanisms for developing community-based biofilms. These bacterial aggregates are of clinical importance, as they are a major source of recurrent disease. Bacterial surface fibers (pili) permit adherence to biotic and abiotic substrates, often in a highly specific manner. The Escherichia coli common pilus (ECP) represents a remarkable family of extracellular fibers that are associated with both disease-causing and commensal strains. ECP plays a dual role in early-stage biofilm development and host cell recognition. Despite being the most common fimbrial structure, relatively little is known regarding its biogenesis, architecture, and function. Here we report atomic-resolution insight into the biogenesis and architecture of ECP. We also derive a structural model for entwined ECP fibers that not only illuminates interbacteria communication during biofilm formation but also provides a useful foundation for the design of novel nanofibers.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Sep 1, 1987·The Pediatric Infectious Disease Journal·J P NataroM M Levine
Apr 2, 1998·Biochemistry·I BaikalovR E Dickerson
Jun 11, 1998·Emerging Infectious Diseases·J P NataroR L Guerrant
Aug 14, 1999·Science·F G SauerG Waksman
May 16, 2002·Molecular Microbiology·Chia-Suei HungScott J Hultgren
Mar 26, 2004·Nature Reviews. Microbiology·James B KaperHarry L Mobley
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
Aug 26, 2004·Molecular Cell·Kirstine L AndersonStephen Matthews
May 22, 2007·PLoS Pathogens·Denis VergerGabriel Waksman
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·María A RendónJorge A Girón
Oct 28, 2008·Cellular and Molecular Life Sciences : CMLS·T Proft, E N Baker
Feb 28, 2009·Nature Protocols·Lawrence A Kelley, Michael J E Sternberg
Apr 10, 2009·Journal of Clinical Microbiology·Dana BlackburnJorge A Girón
Jun 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yong-Fu LiEsther Bullitt
Jun 17, 2009·Cell Host & Microbe·Kimberly A KlineBirgitta Henriques-Normark
Oct 13, 2009·Nature Reviews. Microbiology·Gabriel Waksman, Scott J Hultgren
Dec 8, 2009·Nature Reviews. Microbiology·Matthew A Croxen, B Brett Finlay
Feb 2, 2010·Journal of Bacteriology·Bradley FordGabriel Waksman
May 11, 2010·International Journal of Medical Microbiology : IJMM·Fabiola AvelinoJorge A Girón
May 12, 2010·Nucleic Acids Research·Liisa Holm, Päivi Rosenström
Jun 5, 2010·Microbiology·Timo A LehtiBenita Westerlund-Wikström
Jun 24, 2010·Journal of Structural Biology·Isolde Le TrongRonald E Stenkamp
Aug 28, 2010·Journal of Molecular Biology·Anatoly P DubnovitskyStefan D Knight

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Citations

Jan 29, 2013·Journal of Bacteriology·Katrina T Forest
Jul 17, 2012·Journal of Bacteriology·Verónica I Martínez-SantosJosé L Puente
Jan 12, 2013·Current Protein & Peptide Science·James A Garnett, Steve Matthews
Feb 26, 2013·Current Opinion in Microbiology·Alvin W H LoHan Remaut
Sep 14, 2014·Microbiology·Zoran JaglicSusanne Knøchel
Apr 12, 2016·Future Microbiology·Suzana Meira RibeiroOctávio Luiz Franco
Sep 9, 2015·Frontiers in Microbiology·Efstathios GiaourisManuel Simões
Jul 13, 2016·Protein Science : a Publication of the Protein Society·Wei-Chao LeeJames A Garnett
Apr 8, 2014·Expert Review of Vaccines·James FleckensteinFirdausi Qadri
Jun 10, 2015·Acta Crystallographica. Section F, Structural Biology Communications·James A GarnettSteve J Matthews
Jul 10, 2014·Acta Crystallographica. Section F, Structural Biology Communications·Avi Neznansky, Yarden Opatowsky
Jan 12, 2021·Frontiers in Microbiology·Cinthia Alves-BarrocoAlexandra R Fernandes
Sep 10, 2015·Microbiology Spectrum·Cécile BerneYves V Brun
Oct 16, 2021·Scientific Reports·Sergey PeltekTatyana Goryachkovskaya
Oct 19, 2021·Frontiers in Microbiology·Sébastien MassierJulie Hardouin

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