Structural insights into the cubic-hexagonal phase transition kinetics of monoolein modulated by sucrose solutions

Physical Chemistry Chemical Physics : PCCP
Caleb W ReesePaul E Harper

Abstract

Using DSC (differential scanning calorimetry), we measure the kinetics of the cubic-HII phase transition of monoolein in bulk sucrose solutions. We find that the transition temperature is dramatically lowered, with each 1 mol kg(-1) of sucrose concentration dropping the transition by 20 °C. The kinetics of this transition also slow greatly with increasing sucrose concentration. For low sucrose concentrations, the kinetics are asymmetric, with the cooling (HII-cubic) transition taking twice as long as the heating (cubic-HII) transition. This asymmetry in transition times is reduced for higher sucrose concentrations. The cooling transition exhibits Avrami exponents in the range of 2 to 2.5 and the heating transition shows Avrami exponents ranging from 1 to 3. A classical Avrami interpretation would be that these processes occur via a one or two dimensional pathway with variable nucleation rates. A non-classical perspective would suggest that these exponents reflect the time dependence of pore formation (cooling) and destruction (heating). New density measurements of monoolein show that the currently accepted value is about 5% too low; this has substantial implications for electron density modeling. Structural calculations indicat...Continue Reading

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Citations

Mar 1, 2016·Current Biology : CB·Anders BergströmChris Tyler-Smith
Jul 7, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Adam M SquiresChinedum O Osuji
Oct 26, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maria ChountoulesiCostas Demetzos
Apr 17, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Paul E HarperStephen R Wassall
Nov 19, 2019·Chemistry and Physics of Lipids·Brian C SeperPaul E Harper

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