Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke.

Neurology
Robert LindenbergGottfried Schlaug

Abstract

Motor impairment after stroke has been related to infarct size, infarct location, and integrity of motor tracts. To determine the value of diffusion tensor imaging (DTI) as a predictor of motor outcome and its role as a structural surrogate marker of impairment in chronic stroke, we tested correlations between motor impairment and DTI-derived measures of motor tract integrity. Thirty-five chronic stroke patients with varying degrees of recovery underwent DTI and motor impairment assessments. Fibers originating from the precentral gyrus were traced and separated into pyramidal tract (PT) and alternate motor fibers (aMF). Asymmetry indices of fiber number and regional fractional anisotropy (FA) values comparing lesional with nonlesional hemispheres were correlated with motor impairment scores and compared to an age-matched control group. Fiber number and regional FA value asymmetry significantly differed between the groups with lower values in the patients' lesional hemispheres. Both measures significantly predicted motor impairment with stronger predictions when all motor tracts were combined as compared to predictions using only the PT. The pattern of motor tract damage (PT only vs PT and aMF) led to a classification of mild, m...Continue Reading

Citations

Nov 13, 2013·Nature Reviews. Neurology·Steven L SmallAna Solodkin
Nov 29, 2011·Brain : a Journal of Neurology·Emma A WebbMehul T Dattani
Dec 6, 2011·Cerebral Cortex·Lynley V BradnamWinston D Byblow
Dec 31, 2010·American Journal of Therapeutics·James A Young, Margarita Tolentino
Oct 1, 2011·Journal of Integrative Neuroscience·Warren G DarlingRobert J Morecraft
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Jeff D RileySteven C Cramer
Nov 19, 2011·Stroke; a Journal of Cerebral Circulation·Lynne V GauthierGitendra Uswatte
Jun 3, 2010·Journal of Cognitive Neuroscience·Psyche LouiGottfried Schlaug
Mar 2, 2011·Neurorehabilitation and Neural Repair·Mingguo QiuAndrew J Butler
Aug 2, 2011·Neurorehabilitation and Neural Repair·Alex R CarterMaurizio Corbetta
Sep 2, 2011·Neurology·Sarvenaz Nouri, Steven C Cramer
Aug 13, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason B CarmelJohn H Martin
Jan 25, 2014·Journal of Rehabilitation Research and Development·Vishnumurthy S HednaStephen E Nadeau
Jun 6, 2013·Neural Plasticity·Lin JiangChunshui Yu
Feb 15, 2014·Computational and Mathematical Methods in Medicine·Ming YangGao-jun Teng
Aug 13, 2013·Journal of Neurologic Physical Therapy : JNPT·Michael R BorichLara A Boyd
Sep 10, 2014·Nature Reviews. Neurology·Giovanni Di PinoVincenzo Di Lazzaro
Aug 30, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Tetsuo KoyamaKazuhisa Domen
Dec 2, 2015·Human Brain Mapping·P Simon JonesUNKNOWN SWIFT-Cast investigators
Jan 14, 2016·NeuroImage. Clinical·Alexandra L BorstadDeborah S Nichols-Larsen
Apr 5, 2016·Annals of Clinical and Translational Neurology·Philipp KochFriedhelm C Hummel
Mar 24, 2016·Neural Plasticity·E B PlowA G Machado
Jul 8, 2015·Annals of Neurology·Winston D ByblowSuzanne J Ackerley
Oct 30, 2015·Human Brain Mapping·Mickael DinomaisUNKNOWN AVCnn Study Group
Jul 12, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P ManganottiA Fiaschi
Jun 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Chiaho HuaRobert J Ogg
Oct 30, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Donghyeon KimHyoung-Ihl Kim
Mar 26, 2016·Frontiers in Human Neuroscience·Julia LindowMartin Lotze
Dec 1, 2015·Frontiers in Neurology·Rüdiger J Seitz, Geoffrey A Donnan
Jan 3, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Cathy M Stinear, Nick S Ward
Mar 12, 2016·Social Cognitive and Affective Neuroscience·Matthew E SachsPsyche Loui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.