PMID: 7019221Jul 1, 1981Paper

Structural interaction of cytoskeletal components

The Journal of Cell Biology
M Schliwa, J van Blerkom

Abstract

Three-dimensional cytoskeletal organization of detergent-treated epithelial African green monkey kidney cells (BSC-1) and chick embryo fibroblasts was studied in whole-mount preparations visualized in a high voltage electron microscope. Stereo images are generated at both low and high magnification to reveal both overall cytoskeletal morphology and details of the structural continuity of different filament types. By the use of an improved extraction procedure in combination with heavy meromyosin subfragment 1 decoration of actin filaments, several new features of filament organization are revealed that suggest that the cytoskeleton is a highly interconnected structural unit. In addition to actin filaments, intermediate filaments, and microtubules, a new class of filaments of 2- to 3-nm diameter and 30- to 300-nm length that do not bind heavy merymyosin is demonstrated. They form end-to-side contacts with other cytoskeletal filaments, thereby acting as linkers between various fibers, both like (e.g., actin- actin) and unlike (e.g., actin-intermediate filament, intermediate filament-microtubule). Their nature is unknown. In addition to 2- to 3-nm filaments, actin filaments are demonstrated to form end-to-side contacts with other ...Continue Reading

References

Jun 1, 1977·Die Naturwissenschaften·T Wieland
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R E WebsterK Weber
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K WeberM Osborn
Feb 22, 1979·Nature·P B SchiffS B Horwitz
Jun 1, 1979·The Journal of Cell Biology·B R Telzer, J L Rosenbaum
Jul 1, 1979·The Journal of Cell Biology·J J Wolosewick, K R Porter
Sep 1, 1978·The Journal of Cell Biology·L M Griffith, T D Pollard
Oct 1, 1979·The Journal of Cell Biology·W Ip, D A Fischman
Nov 1, 1976·The American Journal of Anatomy·J J Wolosewick, K R Porter
Jan 1, 1976·Journal of Supramolecular Structure·S BrownJ A Spudich
Jul 1, 1975·Journal of Microscopy·I K Buckley, K R Porter
Nov 5, 1974·Biochimica Et Biophysica Acta·K MaruyamaE Fukada
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M L ShelanskiC R Cantor
Jul 1, 1980·The Journal of Cell Biology·J E Heuser, M W Kirschner
Jul 1, 1980·The Journal of Cell Biology·L G TilneyM J Mulroy
Dec 1, 1980·The Journal of Cell Biology·J H HartwigT P Stossel
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M SchliwaJ G Izant

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Citations

Jan 1, 1996·Cell Motility and the Cytoskeleton·M P Koonce
Jan 1, 1997·Cell Motility and the Cytoskeleton·A Selchow, R Winklbauer
Jul 13, 2000·Cell Motility and the Cytoskeleton·E Frixione
Apr 27, 2002·Cell Motility and the Cytoskeleton·Loraine CampanatiLuiz Henrique Monteiro-Leal
Jan 1, 1990·Cell Motility and the Cytoskeleton·E C Mandeville, C L Rieder
Jan 1, 1990·Cell Motility and the Cytoskeleton·M Sato, W Grasser
Jan 1, 1991·Cell Motility and the Cytoskeleton·J P Heath, B F Holifield
Jan 1, 1991·Cell Motility and the Cytoskeleton·O Skalli, R D Goldman
Jan 1, 1994·Cell Motility and the Cytoskeleton·P G De DeyneJ W Bigbee
Jan 1, 1994·Cell Motility and the Cytoskeleton·L SperlingM Wright
Jan 1, 1995·Cell Motility and the Cytoskeleton·K Collins, P T Matsudaira
Jun 1, 1990·Journal of Neuroscience Research·B T Edmonds, E Koenig
Sep 1, 1991·Journal of Neuroscience Research·M E Dailey, P C Bridgman
Apr 1, 1992·Molecular Reproduction and Development·A J WatsonG A Schultz
Dec 1, 1996·Cancer Metastasis Reviews·M W Klymkowsky
Jul 1, 1987·Cell and Tissue Research·S T KouryB S Eckert
Jan 1, 1987·The Journal of Membrane Biology·V Niggli, M M Burger
Feb 11, 2005·Archives of Microbiology·Marlene Benchimol
Jun 29, 2007·European Biophysics Journal : EBJ·Bruno PontesH Moysés Nussenzveig
Sep 10, 2005·Parasitology Research·A P R GadelhaL H Monteiro-Leal
Sep 10, 2005·Parasitology Research·Marlene Benchimol
Nov 7, 2008·Molecular Neurobiology·Penelope C GeorgesBonnie L Firestein
Nov 1, 1990·Developmental Biology·S D Webster, R W McGaughey
Nov 1, 1992·Developmental Biology·C J Staiger, W Z Cande
Dec 1, 1995·Journal of Biomechanics·D E IngberN Wang
Feb 1, 1992·Journal of the Neurological Sciences·J P BlassA C Baker

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