Structural interactions between pandemic SARS-CoV-2 spike glycoprotein and human Furin protease

BioRxiv : the Preprint Server for Biology
Naveen Vankadari

Abstract

The SARS-CoV-2 pandemic is an urgent global public health emergency and warrants investigating molecular and structural studies addressing the dynamics of viral proteins involved in host cell adhesion. The recent comparative genomic studies highlight the insertion of Furin protease site in the SARS-CoV-2 spike glycoprotein alerting possible modification in the viral spike protein and its eventual entry to host cell and presence of Furin site implicated to virulence. Here we structurally show how Furin interacts with the SARS-CoV-2 spike glycoprotein homotrimer at S1/S2 region, which underlined the mechanism and mode of action, which is a key for host cell entry. Unravelling the structural features of the biding site opens the arena in rising bonafide antibodies targeting to block the Furin cleavage and have great implications in the development of Furin inhibitors or therapeutics.

Related Concepts

Related Feeds

Bioinformatics in Biomedicine (Preprints)

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest preprints on bioinformatics in biomedicine here.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Journal of Immunological Methods
Gemma L Bourne, David J Grainger
Clinical & Translational Immunology
Elisabeth Braun, Daniel Sauter
Proceedings of the National Academy of Sciences of the United States of America
Guan-Sheng JiaoGary Thomas
Expert Opinion on Therapeutic Patents
Frédéric CoutureRobert Day
© 2021 Meta ULC. All rights reserved