Structural Interactions of Curcumin Biotransformed Molecules with the N-Terminal Residues of Cytotoxic-Associated Gene A Protein Provide Insights into Suppression of Oncogenic Activities

Interdisciplinary Sciences, Computational Life Sciences
Akhileshwar Kumar SrivastavaBijoy Krishna Roy

Abstract

Curcumin as a natural product has drawn considerable attention in recent years for its multiple pharmacological activities against various diseases, but more studies are required to understand the curcumin pharmacological action considering its low bioavailability. Though numerous reasons contribute to the low bioavailability of curcumin, one of the important reasons is associated with biotransformation of curcumin through either conjugation or reduction depending on curcumin administration route. The orally administered curcumin (CUR) is metabolised into curcumin glucuronidase (CUR-GLR) and curcumin sulphate by conjugation, whereas dihydroxycurcumin, tetrahydrocurcumin, and hexahydrocurcumin (HHC) are formed by reduction after intraperitoneal administration of curcumin. The main aim of the current study was to investigate the pharmacological properties of curcumin and its biotransformed molecules and its inhibitory potential against CagA (cytotoxic-associated gene A) oncoprotein of Helicobacter pylori. All lead molecules followed the Lipinski's five rules for biological activities, except CUR-GLR, whereas druglikeness scores were obtained for all molecules. Subsequently, molecular docking was employed to analyse the binding af...Continue Reading

References

Dec 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G M HolderA J Ryan
Feb 1, 1991·Planta medica·H P Ammon, M A Wahl
Aug 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·Y J WangJ K Lin
Feb 19, 2000·Current Opinion in Biotechnology·J F Blake
Mar 21, 2002·Nature Reviews. Cancer·Richard M Peek, Martin J Blaser
Jun 26, 2003·Molecular Microbiology·Manfred RohdeRainer Haas
Sep 3, 2004·Nature Reviews. Cancer·Masanori Hatakeyama
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ricky A SharmaWilliam P Steward
Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal
Mar 21, 2006·BMC Complementary and Alternative Medicine·Christopher D LaoDean E Brenner
Jun 16, 2007·Advances in Experimental Medicine and Biology·Jen-Kun Lin
Sep 29, 2007·Biochemical Pharmacology·Ajay GoelBharat B Aggarwal
Jan 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Naomi OhnishiMasanori Hatakeyama
Mar 8, 2008·Cellular and Molecular Life Sciences : CMLS·H HatcherS V Torti
Mar 26, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pierre-Louis BardonnetFrançoise Falson
Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Navneet DhillonRazelle Kurzrock
Sep 9, 2008·Biochemical Pharmacology·Preetha AnandBharat B Aggarwal
Dec 27, 2008·Trends in Pharmacological Sciences·Bharat B Aggarwal, Bokyung Sung
Jan 16, 2009·The FEBS Journal·Alessandro AngeliniDarren J Hart
Feb 5, 2009·The Journal of Antimicrobial Chemotherapy·Nicole WueppenhorstErik Glocker
Feb 11, 2009·Antimicrobial Agents and Chemotherapy·Ronita DeAsish K Mukhopadhyay
Dec 8, 2009·Nature Structural & Molecular Biology·Dragana NesićC Erec Stebbins
Jan 7, 2010·Journal of Neurochemistry·Jiyoung KimKi Won Lee
Apr 22, 2010·CNS Neuroscience & Therapeutics·Tsuyoshi HamaguchiMasahito Yamada
Oct 20, 2010·Current Drug Targets·Hongyu ZhouShile Huang
Mar 1, 2011·The FEBS Journal·Laurent Terradot, Gabriel Waksman
Apr 21, 2011·Chemical Research in Toxicology·Teresa L SerafimPaulo J Oliveira
May 5, 2011·Applied Biochemistry and Biotechnology·Suggula Varun KumarChiranjib Chakraborty
May 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ludovico ButiHidde L Ploegh
Jun 22, 2011·Expert Opinion on Drug Discovery·Xiang-Qun Xie
Dec 14, 2011·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Mark G AlexandrowNagi B Kumar
Mar 6, 2012·Trends in Molecular Medicine·Liang Shen, Hong-Fang Ji
Jul 26, 2012·Molecular Pharmaceutics·Marygorret ObonyoLiangfang Zhang

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