Structural introspection of a putative fluoride transporter in plants

3 Biotech
Aditya Banerjee, Aryadeep Roychoudhury

Abstract

The xenobiotic fluoride is a detrimental toxin which is exported by a double-barrelled fluoride channel (Fluc) in prokaryotes and a single-barrelled fluoride exporter (FEX) in lower eukaryotes. The presence of FEX gene in higher plant species has not been reported till date. In this communication, we have identified FEXs across nine plant species belonging to five different families. Homology modelling predicted the sequential and structural conservation of crucial residues in plant FEXs. It was predicted that the N-terminal segments were the main target sites for phosphorylation. Other post-translational modifications included Arg methylation, Lys acetylation and Cys S-nitrosylation, all of which contribute to protein stability and function. FEXs were predicted to contain lipid moieties which anchor the transporters to the plasma membrane. The crystallizability along with associated properties of plant FEXs was also analyzed to facilitate future experimental analyses. The predicted RNA structure of OsFEX formed several pseudoknots, though no riboswitches could be detected from our prediction. The analysis of upstream regions of FEX in representative plants represented that this gene could be responsive to phytohormone-mediated...Continue Reading

References

Dec 10, 1998·Nucleic Acids Research·K HigoT Korenaga
Dec 22, 1999·Journal of Molecular Biology·N BlomS Brunak
Nov 8, 2003·Structure·Rune LindingRobert B Russell
Dec 19, 2003·Nucleic Acids Research·Qunfeng DongVolker Brendel
Feb 13, 2004·Nucleic Acids Research·Lilia M IakouchevaA Keith Dunker
Jun 25, 2004·Nucleic Acids Research·Peter Bengert, Thomas Dandekar
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Douglas T HessJonathan S Stamler
Apr 26, 2005·Nucleic Acids Research·Yang Zhang, Jeffrey Skolnick
Nov 18, 2005·Gene·Michele A GlozakEdward Seto
Oct 9, 2007·Bioinformatics·Lukasz SlabinskiAdam Godzik
Apr 22, 2008·Nucleic Acids Research·A DereeperO Gascuel
Jun 25, 2009·Bioinformatics·Christophe N MagnanPierre Baldi
Mar 17, 2010·BMC Bioinformatics·Jessica S Reuter, David H Mathews
Dec 20, 2011·Nature·Emma A MorrisonKatherine A Henzler-Wildman
Dec 24, 2011·Science·Jenny L BakerRonald R Breaker
Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Randy B StockbridgeChristopher Miller
May 15, 2013·Nucleic Acids Research·Hamish McWilliamRodrigo Lopez
Aug 31, 2013·ELife·Randy B StockbridgeChristopher Miller
Apr 23, 2014·Nucleic Acids Research·Xavier Robert, Patrice Gouet
May 2, 2014·Nucleic Acids Research·Marco BiasiniTorsten Schwede
Jul 13, 2014·Bioinformatics·Jessen T HavillJeffrey S Thompson
Nov 14, 2014·Bioinformatics·David T Jones, Domenico Cozzetto
Apr 17, 2015·TheScientificWorldJournal·Aditya Banerjee, Aryadeep Roychoudhury
Jun 10, 2015·The Journal of Biological Chemistry·Kathryn D SmithScott A Strobel
Jul 24, 2015·Genesis : the Journal of Genetics and Development·Tanya Z BerardiniEva Huala
Sep 8, 2015·Nature·Randy B StockbridgeSimon Newstead
Dec 17, 2015·Protoplasma·Aditya Banerjee, Aryadeep Roychoudhury
Jan 23, 2016·Frontiers in Plant Science·Muhammad A NawazSaba Hameed
Jul 28, 2016·ELife·Nicholas B LastChristopher Miller
Aug 17, 2017·PloS One·Pawan KumarDinesh Gupta
Sep 4, 2017·Plant Cell Reports·Aditya Banerjee, Aryadeep Roychoudhury
Sep 7, 2017·Protein Science : a Publication of the Protein Society·Roman A LaskowskiJanet M Thornton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Genetics & Development
Chembiochem : a European Journal of Chemical Biology
Takahiro YamauchiNaoki Sugimoto
© 2022 Meta ULC. All rights reserved