PMID: 8938709Jan 1, 1996Paper

Structural model of the outer vestibule and selectivity filter of the Shaker voltage-gated K+ channel

Neuropharmacology
S R Durell, H R Guy

Abstract

A new generation of structural models were developed of the outer vestibule and ion-selective portion of the voltage-gated Shaker K+ channel. Some features of these models are similar to those that we have developed previously [Durrel S. R. and Guy H. R. (1992) Biophys. J. 62, 238-250; Guy H. R. (1990) In Monovalent Cations in Biological Systems (Pasternak C. A., Ed.), pp. 31-58, CRC Press, Boca Raton, FL; Guy H. R. and Durell S. R. (1994) In Molecular Evolution of Physiological processes (Fambrough D., Ed.), pp. 197-212, The Rockefeller University Press, NY; Guy H. R. and Durell S. R. (1995) In Ion Channels and Genetic Diseases (Dawson D., Ed.), pp. 1-16, The Rockefeller University Press, NY] and other features were modified to make the models more consistent with recent experimental findings. The first part of the P segment is postulated, as always, to form a short alpha helix that spans only the outer portion of the membrane. The helix is tilted so that its C-terminal is nearer the pore than its N-terminal. The latter part of the P segment, P2, is postulated to have a relatively elongated conformation that is positioned approximately parallel to the axis of the pore. Four of the P2 segments assemble to form an ion-selective ...Continue Reading

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Citations

Nov 8, 2008·Cell Biochemistry and Biophysics·Sara I Börjesson, Fredrik Elinder
Feb 12, 1998·Trends in Pharmacological Sciences·B Robertson
May 19, 1998·Trends in Pharmacological Sciences·J StriessnigH Glossmann
Jan 16, 1998·Cellular Signalling·N Dascal
Jun 19, 1998·Current Opinion in Structural Biology·M S Sansom
Aug 1, 1997·The Journal of General Physiology·J Zheng, F J Sigworth
Jun 23, 1998·Canadian Journal of Physiology and Pharmacology·D FedidaX Zhang
Feb 17, 2005·Bioelectrochemistry·Aneta D PetelskaZbigniew A Figaszewski
Apr 16, 1998·Neuron·C M Armstrong, B Hille
Jul 4, 1998·Current Biology : CB·M S Sansom
Apr 17, 1998·Biophysical Journal·R E HarrisE Y Isacoff
Apr 16, 1998·The Journal of Biological Chemistry·R L KrausJ Striessnig
Apr 17, 1999·The Journal of Biological Chemistry·S Hoth, R Hedrich
Aug 29, 2002·The Journal of Biological Chemistry·Mauro CataldiRichard W Tsien
Apr 29, 1998·Science·C Armstrong

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