PMID: 12753757May 20, 2003Paper

Structural modeling of drug release from biodegradable porous matrices based on a combined diffusion/erosion process

International Journal of Pharmaceutics
V LemairePatrice Hildgen

Abstract

Biodegradable, porous microspheres exhibit a wide range of release profiles. We propose in this paper a unifying approach based on the dual action of diffusion and erosion to establish which mechanisms are responsible for the variety of release kinetics observed during in vitro experiments. Our modeling procedure leads to the partitioning of the matrix into multiple, identical elements, thus simplifying significantly the mathematical and numerical treatment of the problem. The model equations cannot be solved analytically, since the domain contains a moving interface, and must therefore be solved numerically, using specific methods designed for that purpose. Our model confirms the major role that the relative dominance between diffusion and erosion plays in the release kinetics. In particular, the velocity of erosion, the effective diffusion coefficient of the drug molecule in the wetted polymer, the average pore length, and the initial pore diameter are sensitive parameters, whereas the porosity and the effective diffusion coefficient of the drug in the solvent-filled pores is seen to have little influence, if any, on the release kinetics. The model is confirmed by using release data from biodegradable microspheres with differ...Continue Reading

References

Jan 1, 1996·Biomaterials·A Göpferich
Jan 10, 1998·Journal of Pharmaceutical Sciences·R P BatyckyD A Edwards
Jul 14, 1998·IMA Journal of Mathematics Applied in Medicine and Biology·A J LeeS Hibberd
Sep 2, 1998·European Journal of Drug Metabolism and Pharmacokinetics·R M HernádezJ L Pedraz
Sep 22, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·F M VeroneseS Lora
Jul 27, 1999·Journal of Microencapsulation·D F BainA Smith
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y CapanP P DeLuca
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·J SiepmannR Bodmeier
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·A R Tzafriri
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J M BezemerC A van Blitterswijk
May 29, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J M BezemerJ Feijen
Jun 14, 2000·International Journal of Pharmaceutics·A CharlierG Couarraze
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R A JainN H Shah
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H B RavivarapuP P DeLuca
Sep 7, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·T Ehtezazi, C Washington

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Citations

Jul 17, 2008·Biomechanics and Modeling in Mechanobiology·Fabio GalbuseraGabriele Dubini
Nov 28, 2007·Pharmaceutical Research·Reinhard Vehring
Jun 7, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akihiro MatsumotoHiroyuki Yoshino
Jan 22, 2011·Biomacromolecules·Daniel J Hines, David L Kaplan
Jul 2, 2009·AAPS PharmSciTech·Shivanand Puthli, Pradeep R Vavia
Dec 23, 2009·The Journal of Chemical Physics·A GodecF Merzel
Sep 29, 2005·Drug Delivery·Jingtao HeJianguo Mi
Aug 28, 2007·Journal of Pharmaceutical Sciences·Stefano GiovagnoliCarlo Rossi
Aug 28, 2007·Journal of Pharmaceutical Sciences·Farahidah Mohamed, Christopher F van der Walle
Sep 17, 2010·Journal of Pharmaceutical Sciences·Aiying ZhaoV G J Rodgers
Oct 30, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ashlee N Ford VersyptRichard D Braatz
Jun 7, 2011·International Journal of Pharmaceutics·Susanne FredenbergAnders Axelsson
Dec 25, 2010·International Journal of Pharmaceutics·Luciana Lisa LaoSubbu S Venkatraman
Dec 7, 2010·International Journal of Pharmaceutics·Chelsea K Sackett, Balaji Narasimhan
Jul 27, 2010·International Journal of Pharmaceutics·Boyu MengXiaojin Yin
Jan 22, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Francesca UngaroMaria Immacolata La Rotonda
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Vuk Uskoković
Sep 30, 2008·International Journal of Pharmaceutics·J Siepmann, F Siepmann
Jan 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Patrick Lim SooChristine Allen
Sep 20, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Antigoni MessaritakiSean P Rigby
Aug 2, 2008·Journal of Biomedical Materials Research. Part a·Luciana Lisa LaoNicholas A Peppas
Jul 9, 2009·Journal of Biomedical Materials Research. Part a·P YilgorV Hasirci
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Giuseppe De RosaFrancesca Ungaro
Nov 30, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S KiortsisS Malamataris
Nov 28, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Frank GuBrian Amsden
Sep 15, 2006·International Journal of Pharmaceutics·M Dolores BlancoJosé M Teijón
Jun 22, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Francesca UngaroMaria Immacolata La Rotonda
Jun 30, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Francesca UngaroMaria Immacolata La Rotonda
Apr 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Banu S ZolnikDiane J Burgess
Jan 26, 2006·International Journal of Pharmaceutics·A T Raiche, D A Puleo
Oct 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gayle DuncanChristopher F van der Walle
Aug 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shilpa SantPatrice Hildgen
Jul 10, 2013·International Journal of Pharmaceutics·Jin Seon KwonMoon Suk Kim
May 23, 2015·Therapeutic Delivery·Laura E Strong, Jennifer L West
Jun 1, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Francesca UngaroFabiana Quaglia
Oct 13, 2006·International Journal of Pharmaceutics·Praveen SherAtmaram P Pawar
Dec 8, 2009·International Journal of Pharmaceutics·C MontejoA Fernández-Carballido
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·R van Dijkhuizen-RadersmaJ M Bezemer
May 26, 2017·Journal of Pharmaceutical Sciences·Lucila NavarroIgnacio Rintoul

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