Structural Modification of Nanomicelles through Phosphatidylcholine: The Enhanced Drug-Loading Capacity and Anticancer Activity of Celecoxib-Casein Nanoparticles for the Intravenous Delivery of Celecoxib

Nanomaterials
Liuli XvQizhen Du

Abstract

This study aims to stabilize loaded celecoxib (CX) by modifying the structure of casein nanoparticles through phosphatidylcholine. The results show that Egg yolk phosphatidylcholine PC98T (PC) significantly increased the stability of CX-PC-casein nanoparticles (NPs) (192.6 nm) from 5 min (CX-β-casein-NPs) to 2.5 h at 37 °C. In addition, the resuspended freeze-dried NPs (202.4 nm) remained stable for 2.5 h. Scanning electron microscopy indicated that PC may block the micropore structures in nanoparticles by ultrasonic treatment and hence improve the physicochemical stability of CX-PC-casein-NPs. The stability of the NPs was positively correlated with their inhibiting ability for human malignant melanoma A375 cells. The structural modification of CX-PC-casein-NPs resulted in an increased intracellular uptake of CX by 2.4 times than that of the unmodified ones. The pharmacokinetic study showed that the Area Under Curve (AUC) of the CX-PC-casein-NPs was 2.9-fold higher in rats than that of the original casein nanoparticles. When CX-PC-casein-NPs were intravenously administrated to mice implanted with A375 tumors (CX dose = 16 mg/kg bodyweight), the tumor inhibition rate reached 56.2%, which was comparable to that of paclitaxel (57....Continue Reading

References

May 15, 1983·Journal of Molecular Biology·B A Lewis, D M Engelman
Jun 30, 2000·The New England Journal of Medicine·G SteinbachG Kelloff
Apr 19, 2008·Journal of Dairy Science·D J McMahon, B S Oommen
Jul 21, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Alina ShapiraYoav D Livney
Sep 18, 2010·Chemical Communications : Chem Comm·Chengjie LiuXiqun Jiang
Feb 25, 2011·Cancer Letters·Verena Jendrossek
Nov 17, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alina ShapiraYoav D Livney
Nov 29, 2011·Journal of Dairy Science·R TrejoF Harte
Jan 24, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michal BacharDganit Danino
May 10, 2012·Food & Function·Michal HahamYoav D Livney
Sep 1, 1971·The Journal of Membrane Biology·R FettiplaceD A Haydon
Mar 25, 2014·Current Drug Delivery·Beeravelli SudhakarK V Ramana Murthy
Jun 13, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Tanya TurovskyDganit Danino
Aug 2, 2017·The American Journal of Medicine·Daniel H SolomonJeffrey S Borer
Feb 2, 2018·Biochemistry Research International·Xiang ZhengHong-Yu Zhou

❮ Previous
Next ❯

Citations

Jan 6, 2021·Nanomaterials·Salah M TawfikYong-Ill Lee
Feb 6, 2021·Polymers·Leonard Ionut Atanase

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

Masslynx
Winnonlin Professional

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.