Structural modifications of the brain in acclimatization to high-altitude.

PloS One
Jiaxing ZhangYijun Liu

Abstract

Adaptive changes in respiratory and cardiovascular responses at high altitude (HA) have been well clarified. However, the central mechanisms underlying HA acclimatization remain unclear. Using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) with fractional anisotropy (FA) calculation, we investigated 28 Han immigrant residents (17-22 yr) born and raised at HA of 2616-4200 m in Qinghai-Tibetan Plateau for at least 17 years and who currently attended college at sea-level (SL). Their family migrated from SL to HA 2-3 generations ago and has resided at HA ever since. Control subjects were matched SL residents. HA residents (vs. SL) showed decreased grey matter volume in the bilateral anterior insula, right anterior cingulate cortex, bilateral prefrontal cortex, left precentral cortex, and right lingual cortex. HA residents (vs. SL) had significantly higher FA mainly in the bilateral anterior limb of internal capsule, bilateral superior and inferior longitudinal fasciculus, corpus callosum, bilateral superior corona radiata, bilateral anterior external capsule, right posterior cingulum, and right corticospinal tract. Higher FA values in those regions were associated with decreased or unchanged radial diffusivity coi...Continue Reading

References

Jun 1, 1977·International Journal of Biometeorology·A R Frisancho
Jan 31, 1975·Science·A R Frisancho
Jun 1, 1992·Journal of Applied Physiology·J C LaMannaR M Farrell
Feb 1, 1973·Journal of Applied Physiology·A R FrisanchoH Montoye
Apr 1, 1995·American Journal of Physical Anthropology·A R FrisanchoR Soria
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P W HochachkaJ E Holden
Jan 1, 1993·Journal of Applied Physiology·J ZhuangL G Moore
Feb 14, 1998·Journal of Applied Physiology·L S CurranL G Moore
Mar 3, 1998·Progress in Neurobiology·A J Verberne, N C Owens
Apr 8, 1999·Journal of Applied Physiology·J A BoeroT A Woolsey
Jul 17, 1999·American Journal of Physical Anthropology·A R FrisanchoR Soria
Jul 20, 1999·Journal of Applied Physiology·M S Westerterp-PlantengaB Gardette
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Dec 1, 2000·Human Brain Mapping·C H SalmondK J Friston
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Tom D. BrutsaertJere D. Haas
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·Paul M MaceyRonald M Harper
Jun 25, 2003·Brain : a Journal of Neurology·Hugo D CritchleyRaymond J Dolan
Nov 1, 2003·Sleep Medicine·Mary J MorrellDouglas R Corfield
Feb 10, 2004·The Journal of Physiology·Claudio MarconiPaolo Cerretelli
Feb 11, 2004·Experimental Neurology·Eric D Schwartz, David B Hackney
Nov 25, 2004·Annals of Neurology·Luis ConchaDonald W Gross
Apr 27, 2005·Cognitive, Affective & Behavioral Neuroscience·Christos Constantinidis, Emmanuel Procyk
Jul 9, 2005·Chest·Andreas von Leupoldt, Bernhard Dahme
Dec 3, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amjad KanaanGabriel G Haddad
Jan 18, 2006·Computer Methods and Programs in Biomedicine·Hangyi JiangSusumu Mori
Mar 7, 2006·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Vikas Gulani, Pia C Sundgren
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Sep 19, 2006·High Altitude Medicine & Biology·Tianyi Wu, Bengt Kayser
Nov 9, 2006·Advances in Experimental Medicine and Biology·Mary J Morrell, Gillian Twigg
Mar 14, 2007·American Journal of Physiology. Heart and Circulatory Physiology·D S KimmerlyJ K Shoemaker
Mar 28, 2007·Nature Neuroscience·John A Dani, P Read Montague
Apr 28, 2007·Journal of Applied Physiology·Gerard F A JansenCan Ince
May 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cynthia M Beall
Jun 19, 2007·Biological Psychiatry·Thomas WobrockPeter Falkai

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Citations

Nov 26, 2010·Experimental Brain Research·Xiaodan YanXuchu Weng
Jan 19, 2016·Frontiers in Physiology·Lee TaylorJosh Foster
Jun 6, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Justin S LawleyJamie H Macdonald
Feb 6, 2015·Frontiers in Neuroscience·Zhen YangMichael P Milham
Mar 8, 2017·High Altitude Medicine & Biology·Jiaxing ZhangMing Fan
Jan 21, 2017·AJNR. American Journal of Neuroradiology·W WeiJ Zhang
Feb 4, 2014·Behavioural Brain Research·Olena V BogdanovaPerry F Renshaw
Feb 9, 2018·Journal of Applied Physiology·Shigehiko OgohManabu Shibasaki
Mar 2, 2018·Journal of Magnetic Resonance Imaging : JMRI·Xiaochuan WangJiaxing Zhang
May 28, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jia WangYun You Duan
Apr 12, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Zefeng LiDelong Zhang

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Software Mentioned

SPM2
TBSS
BET ( Brain Extraction Tool
FMRIB
FSL
FDT
DTI Studio
FSL atlas
DCM2MII

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