Structural MRI correlates of amyotrophic lateral sclerosis progression

Journal of Neurology, Neurosurgery, and Psychiatry
Joe SendaGen Sobue

Abstract

Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS. Patients had Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores of ≥36 and did not have the chromosome 9, open reading frame 72 repeat expansion. Six months later, changes in ALSFRS-R (ΔALSFRS-R) scores were calculated and patients were grouped into three categories, namely, patients with slow progression with ΔALSFRS-R scores ≤3 (n=19), intermediate progression with ΔALSFRS-R scores =4, 5 and 6 (n=36) and rapid progression with ΔALSFRS-R scores ≥7 (n=12). We analysed voxel-based morphometry and tract-based spatial statistics among these subgroups and controls. In comparison with controls, patients with ALS showed grey matter atrophy and decreased fractional anisotropy beyond the motor cortex and CST, especially in the frontotemporal lobes and ba...Continue Reading

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Citations

Sep 6, 2018·Acta Neurologica Scandinavica·Juan F Vázquez-CostaTeresa Sevilla
Jul 30, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Julian Grosskreutz
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Feb 16, 2021·The Journal of International Medical Research·Meng-Yu LiuLin Ma
Oct 12, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Aya OguraGen Sobue

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