Structural, nanomechanical, and computational characterization of D,L-cyclic peptide assemblies

ACS Nano
Daniel J RubinNeel S Joshi

Abstract

The rigid geometry and tunable chemistry of D,L-cyclic peptides makes them an intriguing building-block for the rational design of nano- and microscale hierarchically structured materials. Herein, we utilize a combination of electron microscopy, nanomechanical characterization including depth sensing-based bending experiments, and molecular modeling methods to obtain the structural and mechanical characteristics of cyclo-[(Gln-D-Leu)4] (QL4) assemblies. QL4 monomers assemble to form large, rod-like structures with diameters up to 2 μm and lengths of tens to hundreds of micrometers. Image analysis suggests that large assemblies are hierarchically organized from individual tubes that undergo bundling to form larger structures. With an elastic modulus of 11.3 ± 3.3 GPa, hardness of 387 ± 136 MPa and strength (bending) of 98 ± 19 MPa the peptide crystals are among the most robust known proteinaceous micro- and nanofibers. The measured bending modulus of micron-scale fibrils (10.5 ± 0.9 GPa) is in the same range as the Young's modulus measured by nanoindentation indicating that the robust nanoscale network from which the assembly derives its properties is preserved at larger length-scales. Materials selection charts are used to demo...Continue Reading

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Citations

Sep 2, 2016·ACS Nano·Jaehun LeeKi Tae Nam
Dec 10, 2016·The Journal of Physical Chemistry. B·Sajitha SasidharanVibin Ramakrishnan
Jun 22, 2017·Chemical Communications : Chem Comm·Alberto FuertesJavier Montenegro
Aug 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Chao SunWilliam R Dichtel
Sep 1, 2016·Nanotechnology·Melis Sardan EkizMustafa O Guler
Oct 7, 2018·Nature Communications·Kenan P FearsThomas D Clark
Dec 14, 2018·Chemical Science·Alejandro LamasJuan R Granja
Mar 5, 2019·Advanced Science·Jaehun LeeKi Tae Nam
May 4, 2021·Chemical Reviews·Qiao SongSébastien Perrier
May 19, 2021·Journal of the American Chemical Society·Michael J StraussWilliam R Dichtel
Oct 9, 2017·ACS Biomaterials Science & Engineering·Zhuping YinShenzhou Lu
Nov 22, 2019·Journal of the American Chemical Society·Ignacio Insua, Javier Montenegro
Jan 25, 2018·Accounts of Chemical Research·M B Avinash, Thimmaiah Govindaraju
Feb 6, 2020·Chemical Reviews·Toshimi ShimizuNaohiro Kameta
Sep 4, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Jacek K WychowaniecAlberto Saiani

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