Structural nature of the interaction between T lymphocyte surface molecule CD4 and the intracellular protein tyrosine kinase lck

European Journal of Immunology
M A VegaJ L Strominger

Abstract

The strong non-covalent interactions between T lymphocyte surface CD4 or CD8 molecules and the intracellular membrane-associated protein tyrosine kinase lck are likely to mediate the role of CD4 and CD8 molecules in the immune response. The delineation of the structural nature of the CD4/lck and CD8/lck complexes is important for the understanding of the biochemical and functional significance of the interactions. Complementary charged regions in the C-terminal intracytoplasmic portions of CD4 or CD8, and in the N-terminal region of protein tyrosine kinase lck were noted. Peptides spanning these regions, residues 417 to 429 of CD4 and 10 to 22 of lck, were found to specifically dissociate these two molecules in CD4/lck complexes. A structural model of the interaction that accounts for its high stability is proposed.

References

Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C E RuddS F Schlossman
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E K BarberC E Rudd
Jun 1, 1989·Immunology Today·D R Alexander, D A Cantrell
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T MustelinA Altman
Jan 1, 1989·Annual Review of Immunology·B E BiererS J Burakoff
Aug 4, 1988·Nature·M M Davis, P J Bjorkman
Jan 1, 1988·Annual Review of Biochemistry·Y Yarden, A Ullrich
Oct 1, 1988·Molecular and Cellular Biology·A VeilletteJ B Bolen
Oct 1, 1988·Journal of Cellular Biochemistry·R M PerlmutterC B Wilson
Jan 1, 1987·Annual Review of Biophysics and Biophysical Chemistry·E T Kaiser, F J Kézdy
Jan 1, 1984·Annual Review of Biochemistry·D Eisenberg

❮ Previous
Next ❯

Citations

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J ShinJ L Strominger
Sep 7, 1995·Annals of the New York Academy of Sciences·K S RavichandranS J Burakoff
Jul 21, 1998·The Journal of Biological Chemistry·M HuseS C Harrison
Feb 17, 1995·The Journal of Biological Chemistry·A C CarreraC Martinez
Nov 26, 1998·The Journal of Biological Chemistry·R S LinH F Lodish
Jan 1, 1991·European Journal of Immunology·N OdumJ A Ledbetter
Jan 25, 1991·Cell·L C CantleyS Soltoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.