PMID: 9644592Jun 30, 1998Paper

Structural organisations of hemoglobin and myoglobin influence their binding behaviour with phenothiazines

International Journal of Biological Macromolecules
J BhattacharyyaR K Poddar

Abstract

Binding modalities of chlorpromazine and trifluoperazine, two widely used antipsychotic phenothiazine drugs with hemoglobin and myoglobin have been studied to understand how the quaternary, tertiary and secondary structural organisations of the proteins regulate the binding process. NaCl-induced alteration in the quaternary structure of hemoglobin influences its binding modality with phenothiazines. Minor alterations in the tertiary structure of thermally denatured myoglobin (denaturation temperature ranging between 30-70 degrees C) do not affect its affinity and the modality of binding with the drugs, but alterations in the secondary structure of the protein denatured at temperatures between 70-80 degrees C influence its binding.

References

Aug 1, 1976·Biochemical Pharmacology·C Y LeeT M Brody
Oct 1, 1990·International Journal of Biological Macromolecules·M BhattacharyyaR K Poddar
Mar 30, 1990·Biochemical and Biophysical Research Communications·M BhattacharyyaR K Poddar
Mar 30, 1990·Biochemical and Biophysical Research Communications·E A KappC G Whiteley
Jun 1, 1986·Biochimie·J PietteA Van de Vorst
Jan 21, 1967·Nature·G S Tulloch, B R Hershenov
Jun 1, 1994·Biochemical Pharmacology·J BhattacharyyaR K Poddar

❮ Previous
Next ❯

Citations

Jun 7, 2006·The Protein Journal·Manoj KarAbhay Sankar Chakraborti
Mar 12, 2011·Journal of Applied Toxicology : JAT·Bibaswan MondalMaitree Bhattacharyya
Apr 20, 2016·Journal of Biomolecular Structure & Dynamics·Paromita SealRajen Haldar
Aug 16, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Arindam SahaMaitree Bhattacharyya
Jan 4, 2017·Journal of Photochemistry and Photobiology. B, Biology·Sauradipta Banerjee
Jan 18, 2011·The Journal of Pharmacy and Pharmacology·Subhrojit SenAbhay Sankar Chakraborti
Jun 6, 2007·Molecular and Cellular Biochemistry·Subhrojit SenAbhay Sankar Chakraborti
Dec 29, 2004·Biophysical Chemistry·Subhrojit SenAbhay Sankar Chakraborti
Jan 29, 2008·Colloids and Surfaces. B, Biointerfaces·Mohammad Arif CheemaVíctor Mosquera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here