PMID: 8597601Mar 1, 1996Paper

Structural organization and chromosomal localization of the human ribosomal protein L9 gene

Biochimica Et Biophysica Acta
K MazurukI R Rodriguez

Abstract

The intron-containing gene for the human ribosomal protein L9 has been cloned, sequenced and localized. The gene is approximately 5.5 kb in length and contains 8 exons. Splice sites follow the AG/GT consensus rule. The message for human rpL9 is 712 nt in length and is detected in all tissues examined. In the adult, expression is highest in retina and liver while brain shows highest expression among the fetal tissues tested. The transcription start site contains an oligopyrimidine tract, TTCTTTCTT, similar to those found in other ribosomal protein genes. As in other previously characterized ribosomal protein genes, a TATA box is absent from the 5' flanking region but a number of elements recognized by common transcription factors are present including Sp1 sites, CACCC boxes, inverted CCAAT boxes, and GATA elements. Another possible element of interest in the rpL9 5' flanking region is RFX1 also found in the well characterized rat rpL30 promoter. The gene was mapped by fluorescent in situ hybridization to band 13p of chromosome 4. At least 8 possible pseudogenes are present in the human genome, one of which is on Xp. As assessed by Southern 'Zoo-blot' analysis and direct cDNA sequence comparison, the human ribosomal protein L9 ge...Continue Reading

References

Sep 16, 1992·Biochemical and Biophysical Research Communications·K KasJ Merregaert
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J C PierceB Sauer
Jul 11, 1992·Nucleic Acids Research·I R Rodriguez, G J Chader
Jan 11, 1992·Nucleic Acids Research·S Faisst, S Meyer
Dec 2, 1991·Biochimica Et Biophysica Acta·P ColomboM Fried
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S LevyO Meyuhas
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K ShigaH Okamoto
Sep 14, 1990·Gene·K SuzukiI G Wool
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N Hariharan, R P Perry
Jun 1, 1989·Microbiological Reviews·J R Warner
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R Moura-NetoR P Perry
Feb 15, 1989·Analytical Biochemistry·D B Schowalter, S S Sommer
May 1, 1989·Molecular and Cellular Biology·S Chung, R P Perry
Aug 1, 1986·Molecular and Cellular Biology·D D RhoadsD J Roufa
Sep 11, 1993·Nucleic Acids Research·N HoriK Matsubara
Sep 10, 2005·The Journal of Clinical Investigation·Walter J LukiwNicolas G Bazan

❮ Previous
Next ❯

Citations

Oct 4, 2011·Clinical and Molecular Allergy : CMA·Laurie S DavisDavid A Khan
Dec 2, 2000·Differentiation; Research in Biological Diversity·M Bévort, H Leffers
Dec 15, 2010·PloS One·Anzor G GvritishviliJoyce Tombran-Tink
Oct 5, 2006·American Journal of Epidemiology·Juan P CasasAroon D Hingorani
Jul 27, 2001·The Journal of Biological Chemistry·M R EversJ U Baenziger
May 20, 1998·Genome Research·N KenmochiD C Page

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.