Structural organization of long-range GABAergic projection system of the hippocampus

Frontiers in Neuroanatomy
Shozo Jinno


GABA is a key mediator of neural activity in the mammalian central nervous system, and a diverse set of GABAergic neurons utilize GABA as a transmitter. It has been widely accepted that GABAergic neurons typically serve as interneurons while glutamatergic principal cells send excitatory signals to remote areas. In general, glutamatergic projection neurons monosynaptically innervate both principal cells and local GABAergic interneurons in each target area, and these GABAergic cells play a vital role in modulation of the activity of principal cells. The formation and recall of sensory, motor and cognitive representations require coordinated fast communication among multiple areas of the cerebral cortex, which are thought to be mostly mediated by glutamatergic neurons. However, there is an increasing body of evidence showing that specific subpopulations of cortical GABAergic neurons send long-range axonal projections to subcortical and other cortical areas. In particular, a variety of GABAergic neurons in the hippocampus project to neighboring and remote areas. Using anatomical, molecular and electrophysiological approaches, several types of GABAergic projection neurons have been shown to exist in the hippocampus. The target areas...Continue Reading


Apr 8, 2011·Annual Review of Neuroscience·Gord Fishell, Bernardo Rudy
Dec 31, 2011·Neurobiology of Aging·Vincent VillettePatrick Dutar
Apr 17, 2012·Neuroscience Letters·Virawudh SoontornniyomkijCristian L Achim
Feb 12, 2013·Current Opinion in Neurobiology·Antonio CaputiHannah Monyer
Jan 19, 2016·The Journal of Comparative Neurology·Vincent VilletteAgnès Baude
Sep 29, 2017·Physiological Reviews·Kenneth A PelkeyChris J McBain
Oct 12, 2017·Frontiers in Neuroanatomy·Audrey Mercer, Alex M Thomson
Feb 16, 2016·Journal of Neuroscience Research·Alexander J McDonald, David D Mott
Oct 15, 2019·ELife·Zoé Christenson WickEsther Krook-Magnuson
Aug 5, 2020·Nature Reviews. Neuroscience·Sarah Melzer, Hannah Monyer

Related Concepts

Projections and Predictions
Entire Central Nervous System
Structure of Cortex of Kidney
Genus Hippocampus
Cell Septum
Structure of Hippocampal Formation
Entire Hippocampus

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Shozo JinnoPeter Somogyi
The European Journal of Neuroscience
Toshio Miyashita, Kathleen Rockland
© 2020 Meta ULC. All rights reserved