PMID: 3756949Jul 1, 1986Paper

Structural properties of hyaluronic acid in moderately concentrated solutions

Carbohydrate Research
M TerbojevichF Pregnolato

Abstract

The solution properties of hyaluronic acid having various d.p. values have been examined at physiological pH and ionic strength by light-scattering techniques at various concentrations. The angular dependence of Kc/R0 was linear at low concentrations, whereas substantial curvature was present at small angles on increasing the concentration. This phenomenon was affected by the conditions of centrifugation. Moreover, the function Kc/R0 exhibited a maximum value at concentrations of polymer inversely related to the molecular weight. The maximum concentration was always higher than the critical concentration. Ageing, molecular-weight distribution, and polymer purity influenced the light-scattering response. A model is proposed in which the polysaccharide chains intertwine at relatively low concentrations of polymer and become entangled at high concentration, eventually leading to a non-homogeneous polymer network.

Citations

Feb 22, 2002·Biomedical Chromatography : BMC·Mitsuhiro KinoshitaKazuaki Kakehi
Oct 16, 2002·Biomedical Chromatography : BMC·L SoltésD Bakos
Apr 8, 2014·Carbohydrate Polymers·Mikael Bjerg CaspersenKristoffer Tømmeraas
May 1, 1992·Current Eye Research·F A Bettelheim, N Popdimitrova
Mar 27, 2009·Journal of Biomedical Materials Research. Part a·A BorzacchielloL Ambrosio
Jul 30, 2016·Biorheology·L Martin-Alarcon, T A Schmidt
Jan 7, 2018·Glycoconjugate Journal·Yanfei PengRobert J Linhardt
Jul 29, 2020·Diagnostics·Wolfgang G K Müller-Lierheim
Mar 23, 2005·Carbohydrate Research·Mary K Cowman, Shiro Matsuoka
Feb 19, 2002·Chemical Reviews·Lubomír Lapcík L Jr andPeter Chabrecek
Sep 5, 2008·Carbohydrate Polymers·Zuzana BezákováVladimír Velebný

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