Structural rearrangement within an enveloped virus upon binding to the host cell.

Journal of Virology
David G Meckes, J W Wills

Abstract

We have made the surprising discovery that the interactions of herpes simplex virus with its initial cell attachment receptor induce a rapid and highly efficient structural change in the tegument, the region of the virion situated between the membrane and the capsid. It has been known for nearly a decade that viruses can trigger host signaling pathways when they bind to receptors on the cell surface; however, until now there has been no evidence that a signal can be sent in reverse--from the "outside in"--across a viral membrane. Evidence for this signaling event was found during studies of UL16, a tegument protein that is conserved among all the herpesviruses. Previous work has demonstrated that UL16 is bound to capsids isolated from the cytoplasm of infected cells, but this interaction is destabilized during subsequent egress steps, leading to release of the extracellular virion. Pretreatment with N-ethylmaleimide, a small, membrane-permeating compound that covalently modifies free cysteines, restabilizes the interaction, thereby permitting the capsid-UL16 complex to be isolated following disruption of virions with NP-40. In the experiments described here, we found that the natural signal for release of UL16 from capsids is s...Continue Reading

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Citations

Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kevin Patrick BohannonGregory Allan Smith
Jul 1, 2011·Journal of Virology·Silke ManingerZsolt Ruzsics
Jun 6, 2009·Journal of Virology·William W Newcomb, Jay C Brown
Aug 24, 2012·Journal of Virology·Pooja ChadhaJohn W Wills
Jan 1, 2010·Journal of Virology·Amy L HarperJohn W Wills
Oct 14, 2011·Viruses·Sofia V ZaichickGregory A Smith
Jun 26, 2012·Annual Review of Microbiology·Gregory Smith
Jun 15, 2018·Journal of Virology·Gina R DanielGregory A Smith
Feb 7, 2020·MSphere·Tri Komala SariAnthony V Nicola
Dec 31, 2020·Viruses·Christos DogrammatzisMaria Kalamvoki

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