Structural remodeling of nucleus ambiguus projections to cardiac ganglia following chronic intermittent hypoxia in C57BL/6J mice.

The Journal of Comparative Neurology
Min LinZixi ' Jack ' Cheng

Abstract

The baroreflex control of heart rate (HR) is reduced following chronic intermittent hypoxia (CIH). Since the nucleus ambiguus (NA) plays a key role in baroreflex control of HR, we examined whether CIH remodels vagal efferent projections to cardiac ganglia. C57BL/6J mice (3-4 months of age) were exposed to either room air (RA) or CIH for 3 months. Confocal microscopy was used to examine NA axons and terminals in cardiac ganglia following Fluoro-Gold (FG) injections to label cardiac ganglia, and microinjections of tracer DiI into the left NA to anterogradely label vagal efferents. We found that: 1) Cardiac ganglia were widely distributed on the dorsal surface of the atria. Although the total number of cardiac ganglia did not differ between RA and CIH mice, the size of ganglia and the somatic area of cardiac principal neurons (PNs) were significantly decreased (P < 0.01), and the size of the PN nuclei was increased following CIH (P < 0.01). 2) NA axons entered cardiac ganglia and innervated PNs with dense basket endings in both RA and CIH mice, and the percentage of innervated PNs was similar (RA: 50 +/- 1.0%; CIH: 49 +/- 1.0%; P > 0.10). In CIH mice, however, swollen cardiac axons and terminals without close contacts to PNs were ...Continue Reading

References

May 1, 1965·Journal of Neurophysiology·E HennemanD O Carpenter
Nov 1, 1980·Journal of Gerontology·G J Kelliher, S T Conahan
Jan 1, 1993·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·S Wolf
Jan 1, 1993·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·M H HuangJ A Armour
Apr 28, 1997·The Journal of Comparative Neurology·Z ChengF J Doyle
May 18, 1999·Cardiovascular Research·J A Armour
Jul 20, 1999·The Anatomical Record·J Y Jew, T H Williams
Jul 21, 2000·The Anatomical Record·D A HopkinsJ A Armour
Feb 24, 2001·Journal of Cardiovascular Electrophysiology·A C LaiB G Sharifi
May 2, 2001·The Journal of Comparative Neurology·R J Phillips, T L Powley
Mar 26, 2002·Autonomic Neuroscience : Basic & Clinical·Robert E Schmidt
Aug 30, 2002·International Review of Neurobiology·Robert E Schmidt
Jul 25, 2003·Autonomic Neuroscience : Basic & Clinical·Robert J PhillipsTerry L Powley
May 1, 1965·Journal of Neurophysiology·E HENNEMAND O CARPENTER
Nov 18, 2003·Journal of Applied Physiology·Zixi ChengDavid Gozal
Feb 26, 2004·Paediatric Respiratory Reviews·David Gozal, Louise M O'Brien
Mar 6, 2004·American Journal of Physiology. Cell Physiology·Chung-Yu LiSheau-Huei Chueh
Jun 17, 2004·Journal of Neuropathology and Experimental Neurology·Robert E SchmidtAnders A F Sima
Oct 14, 2004·Anatomy and Embryology·Robert J PhillipsTerry L Powley
May 26, 2005·Journal of Neurophysiology·Lorne M Mendell
Jul 9, 2005·Journal of Applied Physiology·M J CampenC P O'Donnell
Oct 6, 2005·Neurobiology of Aging·Robert E SchmidtLucie N Beaudet
May 20, 2006·The Journal of Physiology·Kevin D MonahanChester A Ray
Jun 24, 2006·Neurobiology of Aging·Robert J PhillipsTerry L Powley
Jul 29, 2006·Autonomic Neuroscience : Basic & Clinical·Pedro Dall'agoMaria Cláudia Irigoyen
Jul 7, 2007·The Journal of Comparative Neurology·Jing AiZixi Cheng

❮ Previous
Next ❯

Citations

Aug 17, 2011·American Journal of Respiratory and Critical Care Medicine·Philippe Connes
May 7, 2013·Comptes rendus biologies·Philippe Connes, Thomas D Coates
Sep 8, 2012·Respiratory Physiology & Neurobiology·David GozalLeila Kheirandish-Gozal
Jan 30, 2016·Oxidative Medicine and Cellular Longevity·Jeffrey HatcherZixi Jack Cheng
May 11, 2010·Respiratory Physiology & Neurobiology·Olga DergachevaDavid Mendelowitz
Mar 5, 2016·Nature Reviews. Endocrinology·Alex Gileles-HillelDavid Gozal
Mar 3, 2009·Progress in Cardiovascular Diseases·Allan I Pack, Thorarinn Gislason
Mar 26, 2016·Frontiers in Pediatrics·Gyuyoup KimEung-Kwon Pae
Feb 14, 2015·Sleep Medicine Reviews·Alex Gileles-HillelDavid Gozal
Jun 20, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anabel L Castro-GrattoniUNKNOWN Spanish Sleep Network
Dec 6, 2019·Cardiology in Review·Amandeep AujlaSeah H Lim
Dec 8, 2017·Annals of Hematology·Vikram M RaghunathanSeah H Lim
Aug 22, 2018·Frontiers in Endocrinology·Sarah N Framnes, Deanna M Arble
Dec 10, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jin ChenZixi Jack Cheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.