PMID: 9437744Jan 23, 1998Paper

Structural requirements and mechanism of the pressor activity of Leu-Val-Val-hemorphin-7, a fragment of hemoglobin beta-chain in rats

Peptides
S MoisanF Rioux

Abstract

A rat blood pressure assay was used to perform a structure-activity relationship study (SAR) of Leu-Val-Val-hemorphin-7 (LVV-H7), a fragment of hemoglobin (Hb) beta-chain, elucidate the mechanisms of its cardiovascular effects, and test its potential involvement in the pressor activity of diaspirin crosslinked Hb (DCLHb), a recently developed Hb-based oxygen carrier. The SAR study revealed that the C-terminal-Arg-Phe-amino acid sequence of LVV-H7 contained the main determinants of the pressor activity of this peptide. Drug interaction studies using various inhibitory drugs (e.g., phentolamine, clonidine, etc.) and LVV-H7 showed that the pressor effect and tachycardia elicited by LVV-H7 involved the activation of the sympathetic nervous system (SNS). Additional studies using phenytoin (sodium channel blocker), [Tic7]H7(5-7)-NH2 (putative antagonist of receptors for LVV-H7) and H7(5-7)-NH2, an amidated C-terminal fragment of LVV-H7, suggested that LVV-H7 activated the SNS by interacting with specific receptors functionally coupled with phenytoin-sensitive sodium channels. The pressor effect and tachycardia caused by LVV-H7 were potentiated by captopril, suggesting that the angiotensin converting enzyme may contribute to the inact...Continue Reading

References

Nov 30, 1992·Biochemical and Biophysical Research Communications·J M PiotD Thomas
Dec 1, 1992·Neurochemical Research·N BarkhudaryanA Galoyan
Apr 30, 1992·Biochemical and Biophysical Research Communications·E L GlämstaF Nyberg
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S R SnyderJ A Walder
Sep 22, 1987·Brain Research·J F FloodJ E Morley
Jun 17, 1986·European Journal of Pharmacology·V BrantlA Herz
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H Y YangE Costa
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·S S KatsuyamaK Bradley
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·A Gulati, S Rebello
Mar 11, 1996·FEBS Letters·N DagouassatJ M Piot

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Citations

Jul 14, 2006·Analytical and Bioanalytical Chemistry·Harald JohnWolf-Georg Forssmann
Aug 6, 2013·Peptides·Natalia M RibeiroCamila S Dale
Sep 3, 2010·The AAPS Journal·Ivone GomesLakshmi A Devi
Dec 8, 2009·Neurochemical Research·Nina BarkhudaryanFriedrich Lottspeich
Mar 3, 2004·Journal of Neuroscience Research·Anne PoljakGeorge A Smythe
Jan 18, 2005·Peptides·Camila Squarzoni DaleEmer Suavinho Ferro
Feb 28, 2006·Molecular & Cellular Proteomics : MCP·Maria FälthPer E Andren
Oct 16, 2019·Scientific Reports·Amanat AliRanjit Vijayan
Jan 27, 2019·Drug Development Research·Petar TodorovJana Tchekalarova
Nov 12, 2019·Frontiers in Pharmacology·Amanat AliMohammed Akli Ayoub
Dec 26, 2002·The Journal of Biological Chemistry·Vanessa RioliEmer S Ferro
Jan 1, 2021·International Journal of Molecular Sciences·Amanat AliRanjit Vijayan
Feb 20, 2020·Peptides·Fengmei WeiYuhong Jing
Apr 4, 2021·Pharmaceuticals·Mohammed Akli Ayoub, Ranjit Vijayan
Nov 20, 2020·Neuropharmacology·Andrea S HeimannEmer S Ferro
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Przemyslaw MielczarekJerzy Silberring

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