Structural requirements for the inhibition of phthalate ester hydrolysis in rainbow trout by methylenedioxyphenyl compounds

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M J Melancon, J J Lech

Abstract

1. The ability of a number of methylenedioxyphenyl compounds and paraoxon to inhibit the hydrolysis and oxidation of di-2-ethylhexyl phthalate by rainbow trout tissue preparations was examined. 2. In addition to paraoxon, only the methylenedioxyphenyl compounds with long side-chains (piperonyl butoxide and tropital) inhibited the hydrolysis of di-2-ethylhexyl phthalate by trout liver subcellular fractions and trout serum. 3. Paraoxon decreased the production of the major metabolite of di-2-ethylhexyl phthalate by trout liver microsomes (+ NADPH) suggesting that this metabolite arises via further metabolism of mono-2-ethylhexyl phthalate.

References

Jan 1, 1987·Drug Metabolism Reviews·F J Leinweber

Related Concepts

Metabolic Process, Cellular
Diethylhexyl Phthalate
Depression, Chemical
Structure-Activity Relationship
Phthalates
Phthalate
Microsomes, Liver
Oxidation
Salvelinus
Metabolic Pathway

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