PMID: 6717460May 1, 1984Paper

Structural requirements for the mutagenicity of environmental nitroarenes

Mutation Research
G Klopman, H S Rosenkranz


The nitroarenes comprise a large group of widely distributed environmental agents some of which are extraordinarily mutagenic while others are devoid of such activity. A newly developed computer program has been used to determine which structural features of these molecules might account for this broad spectrum of activities. Using Salmonella mutagenicity data for 53 nitroarenes , 2 fragments associated with activity and 2 deactivating fragments have been identified. The coexistence of an active and a deactivating fragment on the same molecule results in a nitroarene possessing marginal or no mutagenicity. The activity of 47 of 53 nitroarenes was correctly predicted by this procedure. Most of the discrepancies involved hexa- and heptacyclic nitroarenes which were predicted to be active but reported to be inactive. The 'CASE' program can be used to predict the mutagenicity of the many untested nitroarenes identified in the ambient environment.


Jun 1, 1979·Chemico-biological Interactions·J D ScribnerN K Scribner
Mar 1, 1982·Mutation Research·H S Rosenkranz
Apr 1, 1981·Journal of Applied Toxicology : JAT·T C Pederson, J S Siak
Jan 1, 1983·Chemico-biological Interactions·C LuB E McCarry
Jan 1, 1983·Environmental Mutagenesis·E C McCoyR Mermelstein
Jan 1, 1984·Environmental Mutagenesis·H S RosenkranzY Y Haimes
Oct 15, 1982·Biochemical and Biophysical Research Communications·E C McCoyH S Rosenkranz
Sep 1, 1981·Mutation Research·G R Mohn
May 1, 1983·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P Shubik
Jul 1, 1981·Mutation Research·R MermelsteinH S Rosenkranz
Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
Jan 1, 1981·Environmental Mutagenesis·E C McCoyR Mermelstein
Sep 1, 1981·Mutation Research·E C McCoyR Mermelstein
Dec 1, 1981·Mutation Research·E J LaVoieD Hoffmann
Dec 1, 1982·Environmental Science & Technology·T RamdahlA Bjoerseth

❮ Previous
Next ❯


Jan 1, 1990·Teratogenesis, Carcinogenesis, and Mutagenesis·H S Rosenkranz, G Klopman
Feb 1, 1990·Mutation Research·H S Rosenkranz, G Klopman
Jan 16, 1994·Mutation Research·V Mersch-SundermannG Klopman
Nov 1, 1989·Mutation Research·H S Rosenkranz, G Klopman
Oct 1, 1990·Mutation Research·R Buzzi, F E Würgler
Mar 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H S Rosenkranz, G Klopman
Jan 1, 1996·SAR and QSAR in Environmental Research·H S RosenkranzG Klopman
Feb 16, 2000·SAR and QSAR in Environmental Research·N PollackH S Rosenkranz
Jan 1, 1988·Journal of Toxicology and Environmental Health·S NesnowA Richard
Oct 24, 2001·Environmental Health Perspectives·A R Cunningham, H S Rosenkranz
Sep 1, 1985·Environmental Health Perspectives·G Klopman
Dec 1, 1991·Environmental Health Perspectives·G Klopman, H Rosenkranz
Feb 4, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·Alfonso Pérez-GarridoM Natália D S Cordeiro
Jan 1, 1990·Drug Metabolism Reviews·P P Fu
Jan 1, 1986·Critical Reviews in Toxicology·H Tokiwa, Y Ohnishi
Jan 1, 1986·Environmental Mutagenesis·G KlopmanH S Rosenkranz
Jan 1, 1986·Environmental Mutagenesis·M R FriersonH S Rosenkranz

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.