PMID: 6717460May 1, 1984Paper

Structural requirements for the mutagenicity of environmental nitroarenes

Mutation Research
G Klopman, H S Rosenkranz

Abstract

The nitroarenes comprise a large group of widely distributed environmental agents some of which are extraordinarily mutagenic while others are devoid of such activity. A newly developed computer program has been used to determine which structural features of these molecules might account for this broad spectrum of activities. Using Salmonella mutagenicity data for 53 nitroarenes , 2 fragments associated with activity and 2 deactivating fragments have been identified. The coexistence of an active and a deactivating fragment on the same molecule results in a nitroarene possessing marginal or no mutagenicity. The activity of 47 of 53 nitroarenes was correctly predicted by this procedure. Most of the discrepancies involved hexa- and heptacyclic nitroarenes which were predicted to be active but reported to be inactive. The 'CASE' program can be used to predict the mutagenicity of the many untested nitroarenes identified in the ambient environment.

References

Jun 1, 1979·Chemico-biological Interactions·J D ScribnerN K Scribner
Mar 1, 1982·Mutation Research·H S Rosenkranz
Apr 1, 1981·Journal of Applied Toxicology : JAT·T C Pederson, J S Siak
Jan 1, 1983·Chemico-biological Interactions·C LuB E McCarry
Jan 1, 1983·Environmental Mutagenesis·E C McCoyR Mermelstein
Jan 1, 1984·Environmental Mutagenesis·H S RosenkranzY Y Haimes
Oct 15, 1982·Biochemical and Biophysical Research Communications·E C McCoyH S Rosenkranz
Sep 1, 1981·Mutation Research·G R Mohn
May 1, 1983·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P Shubik
Jul 1, 1981·Mutation Research·R MermelsteinH S Rosenkranz
Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
Jan 1, 1981·Environmental Mutagenesis·E C McCoyR Mermelstein
Sep 1, 1981·Mutation Research·E C McCoyR Mermelstein
Dec 1, 1981·Mutation Research·E J LaVoieD Hoffmann
Dec 1, 1982·Environmental Science & Technology·T RamdahlA Bjoerseth

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Citations

Jan 1, 1990·Teratogenesis, Carcinogenesis, and Mutagenesis·H S Rosenkranz, G Klopman
Feb 1, 1990·Mutation Research·H S Rosenkranz, G Klopman
Jan 16, 1994·Mutation Research·V Mersch-SundermannG Klopman
Nov 1, 1989·Mutation Research·H S Rosenkranz, G Klopman
Oct 1, 1990·Mutation Research·R Buzzi, F E Würgler
Mar 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H S Rosenkranz, G Klopman
Jan 1, 1996·SAR and QSAR in Environmental Research·H S RosenkranzG Klopman
Feb 16, 2000·SAR and QSAR in Environmental Research·N PollackH S Rosenkranz
Jan 1, 1988·Journal of Toxicology and Environmental Health·S NesnowA Richard
Oct 24, 2001·Environmental Health Perspectives·A R Cunningham, H S Rosenkranz
Sep 1, 1985·Environmental Health Perspectives·G Klopman
Dec 1, 1991·Environmental Health Perspectives·G Klopman, H Rosenkranz
Feb 4, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·Alfonso Pérez-GarridoM Natália D S Cordeiro
Jan 1, 1990·Drug Metabolism Reviews·P P Fu
Jan 1, 1986·Critical Reviews in Toxicology·H Tokiwa, Y Ohnishi
Jan 1, 1986·Environmental Mutagenesis·G KlopmanH S Rosenkranz
Jan 1, 1986·Environmental Mutagenesis·M R FriersonH S Rosenkranz

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