PMID: 7536038Apr 5, 1995Paper

Structural specificity of substrate for S-adenosylmethionine:protein arginine N-methyltransferases

Biochimica Et Biophysica Acta
N RawalS Kim

Abstract

The enzymatic methylation of polypeptides on the guanidino group of internal arginine residues by S-adenosylmethionine:protein arginine N-methyltransferase (protein methylase I) yields NG-monomethylarginine, NG,NG-dimethylarginine and NG,NG-dimethylarginine. It has commonly been observed that these arginine residues are present in glycine-and-arginine rich motifs. To understand structural features which are essential for serving as the methyl acceptor for protein methylase I, we have investigated substrate capacities of several synthetic oligopeptides whose sequences are homologous and/or analogous to the methyl acceptor region of the naturally occurring arginine-methylated proteins. These studies have led to the following conclusions. (i) The preferred amino-acid sequence of methyl-accepting peptides was shown to be an arginine-containing peptide with glycine in both the N- and C-flanking positions. While a tetrapeptide with such a sequence (residues 106-109 of bovine myelin basic protein) exhibited almost negligible substrate activity, an overlapping hexapeptide was a moderate substrate. (ii) Substitution of the C-flanking glycine in GKGRGL (residues 104-109 of myelin basic protein) with histidine, phenylalanine, lysine or as...Continue Reading

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Citations

May 15, 2003·Biochemical and Biophysical Research Communications·Yongchul LimSangduk Kim
Dec 29, 2000·Journal of the American College of Cardiology·R H BögerJ P Cooke
May 1, 1997·The International Journal of Biochemistry & Cell Biology·S KimW K Paik
Jun 7, 2000·The Biochemical Journal·Y L HyunS Kim
Oct 5, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elizabeth KleinSandra M Wells
Aug 16, 2008·American Journal of Respiratory Cell and Molecular Biology·Sandra M WellsAndrij Holian
Aug 7, 2009·BMC Genomics·Jay VyasMartin R Schiller
Dec 12, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Vallabh O ShahDavid L Vander Jagt
Jul 28, 2012·International Journal of Molecular Sciences·Srinidi Mohan, Ho-Leung Fung
Feb 14, 2014·The Journal of Nutrition, Health & Aging·K HristinaM Trapecar
Aug 28, 2014·Amino Acids·Ada PopoloStefania Marzocco
Oct 6, 2014·Immunology and Allergy Clinics of North America·Angela L LinderholmNicholas J Kenyon
Oct 3, 2012·European Journal of Pharmacology·Xu-Meng ChenJun-Lin Jiang
Mar 14, 2002·Nitric Oxide : Biology and Chemistry·Andrew J Maxwell
Feb 20, 2007·Journal of Immunological Methods·Peng DuanJohn M Aletta
May 10, 2018·Journal of Cellular Physiology·Hamid Reza NejabatiMohammad Nouri
Dec 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Rainer H Böger
Mar 30, 2011·Nature Reviews. Nephrology·Edzard Schwedhelm, Rainer H Böger
Feb 12, 2008·The Journal of Biological Chemistry·Ted M Lakowski, Adam Frankel
Apr 5, 2000·The Journal of Biological Chemistry·M T BedfordS Richard
Feb 1, 2000·The Journal of Biological Chemistry·S KleinD B Rifkin
Apr 2, 2004·The Journal of Biological Chemistry·Donghang ChengMark T Bedford
Mar 3, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dmitri Y Boudko

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