PMID: 2498463Jul 1, 1989Paper

Structural specificity of sugar transport at the blood-nerve barrier

Journal of Neurochemistry
E RechthandS I Rapoport

Abstract

The major component of D-glucose transfer across the membranous sites of the blood-nerve barrier (BNB) occurs via a facilitative mechanism at a rate greater than twice the rate of D-glucose metabolism by nerve. To characterize further properties of monosaccharide transport at the BNB, unidirectional transfer constant (K) values were determined in vivo in tibial nerve of anesthetized rats for radiolabeled mannitol, L-glucose, and a series of D-glucose analogs. K values(X 10(-4) mls-1 g-1) equaled 4.8 for 2-deoxy-D-glucose, 3.7 for D-glucose, 2.3 for 3-O-methyl-D-glucose, 1.4 for D-mannose, 0.6 for D-galactose, 0.2 for mannitol, and 0.19 for L-glucose. The rank order of ratios between K values of a D-hexose and D-glucose, which reflects the rank order of affinity of the system for individual sugars, was 2-deoxy-D-glucose greater than D-glucose greater than 3-O-methyl-D-glucose greater than D-mannose greater than D-galactose. The results demonstrate that the order of substrate affinity of the monosaccharide carrier at the BNB is similar to that at cerebral capillaries and at erythrocytes. At normal concentrations of plasma D-glucose, the contribution of simple passive diffusion to unidirectional D-glucose influx across the BNB equ...Continue Reading

References

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Citations

Jun 1, 1994·Progress in Neurobiology·K C Wadhwani, S I Rapoport
Nov 1, 1991·Metabolism: Clinical and Experimental·A P Mizisin, N A Calcutt
Dec 30, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Liyue HuangMin-Hwa Jasmine Lin
Jan 16, 1999·Neurobiology of Learning and Memory·C P TalleyP E Gold

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