Structural stability of antimicrobial peptides rich in tryptophan, proline and arginine: a computational study.

Journal of Biomolecular Structure & Dynamics
Sathish Kumar MarimuthuLatha Subbiah

Abstract

The host defense peptides or antimicrobial peptides (AMPs) often contain short sequence of amino acids, either positive or negatively charged and express broad-spectrum antibacterial, antiviral and antifungal activity. Many researchers had reported that tryptophan, arginine and proline rich AMPs have a promising source of next-generation antibiotics. Nowadays, AMPs are used as a possible therapeutic source for future antibiotics. In the present study, the amino acid sequences of 2924 AMPs belonging to various sources rich in Tryptophan, Proline and Arginine was chosen for investigation. The AMPs were further categorized according to their source, structure and antimicrobial activities. The AMPs with tryptophan, arginine, proline residues in abundance with maximum sequence length of 20 amino acids alone was obtained. Homology modeling was performed with PEP-FOLD and the modeled structures were evaluated using RAMPAGE to identify the structural information. Further, the stability of peptide in aqueous condition was probed using molecular dynamics simulations.Communicated by Ramaswamy H. Sarma.

References

Nov 21, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·David J SchibliRichard M Epand
Jan 31, 2003·Proteins·Simon C LovellDavid C Richardson
Jun 8, 2006·Biochimica Et Biophysica Acta·David I ChanHans J Vogel
Jul 19, 2006·Clinical Microbiology Reviews·Håvard JenssenRobert E W Hancock
Jan 13, 2012·Annual Review of Pharmacology and Toxicology·Nannette Y Yount, Michael R Yeaman
Apr 11, 2012·Journal of Computational Chemistry·Christopher J R IllingworthChristopher A Reynolds
Jun 6, 2012·Current Drug Targets·Marc TorrentEster Boix
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 28, 2013·Pharmaceuticals·Wataru Aoki, Mitsuyoshi Ueda
May 9, 2014·Protein & Cell·Yibing HuangYuxin Chen
Sep 9, 2015·Frontiers in Immunology·Lukas MartinTobias Schuerholz
Nov 26, 2015·Nucleic Acids Research·Guangshun WangZhe Wang
Jan 11, 2016·World Journal of Microbiology & Biotechnology·Nadin ShagaghiMrinal Bhave
Feb 24, 2016·Antimicrobial Agents and Chemotherapy·C Seth PearsonGeorges Belfort
Jan 14, 2017·Frontiers in Cellular and Infection Microbiology·Margit MahlapuuCamilla Björn
Jan 28, 2017·Scientific Reports·Michiru NishitaYasuhiro Minami
Apr 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Awdhesh Kumar MishraKwang-Hyun Baek
May 26, 2018·Drug Design, Development and Therapy·Tayebeh Farhadi, Seyed MohammadReza Hashemian
Sep 30, 2018·Advanced Drug Delivery Reviews·Austin P VeithAaron B Baker
Oct 30, 2018·Protein and Peptide Letters·Rajeshwari Sinha, Pratyoosh Shukla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Awdhesh Kumar MishraKwang-Hyun Baek
© 2021 Meta ULC. All rights reserved